10. Molecular Signaling Cascades and Gene Regulation

  1. Prof. Dr. Horst Feldmann1,2

Published Online: 26 SEP 2012

DOI: 10.1002/9783527659180.ch10

Yeast: Molecular and Cell Biology, Second Edition

Yeast: Molecular and Cell Biology, Second Edition

How to Cite

Feldmann, H. (ed) (2012) Molecular Signaling Cascades and Gene Regulation, in Yeast: Molecular and Cell Biology, Second Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527659180.ch10

Editor Information

  1. 1

    Adolf Butenandt Institute, Molecular Biology, Ludwig-Maximilians-Universität M¨nchen, Schillerstr. 44, 80336 M¨nchen, Germany

  2. 2

    Ludwig-Thoma-Strasse 22B, 85232 Bergkirchen, Germany

Publication History

  1. Published Online: 26 SEP 2012
  2. Published Print: 22 AUG 2012

ISBN Information

Print ISBN: 9783527332526

Online ISBN: 9783527659180

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Keywords:

  • molecularsignaling cascades;
  • gene regulation;
  • Ras–cAMPsignaling pathway;
  • MAP kinase pathways;
  • stress responses

Summary

• Similar to transcription and the processes coupled to it, molecular signaling cascades and gene regulation are basic requirements for a cell to grow and propagate. In this respect, the signal cascades in humans appear more sophisticated and complex compared to those in yeast. Nonetheless, in many cases principal cues are evolutionarily conserved form yeast to man. Specialized signal cascades, such as for regulating mating switch or filamentation, are reserved for yeast and other fungal organisms. Although many tyrosine-specific kinases do exist in S. cerevisiae, to the best of our knowledge, membrane-bound receptors connected with tyrosine autophosphorylation and subsequent multistep cascades are not found in yeast, while other regulatory circuits, such as the TOR system in the control of nutrient supply or cell integrity and the heat-shock response, are highly conserved.

• After the description of the yeast MAP kinase pathways, regulatory circuits involved in carbon and nitrogen metabolism are discussed, whereby gene activation and repression play an important role. In addition to the heat-shock response, several other pathways are considered to cope with various kinds of other shock phenomena. It is noteworthy to mention that, for example, deleterious attacks of ROS or heavy metals are met in yeast by inducing pathways similar to those observed in mammalian cells. This is also true for membrane-bound activities, which are aimed at protecting cells against hazardous drugs (“PDR”) and means of exporting these out of the cell.