11. Yeast Organellar Biogenesis and Function
- Prof. Dr. Horst Feldmann1,2
Published Online: 26 SEP 2012
Copyright © 2012 Wiley-VCH Verlag GmbH & Co. KGaA
Yeast: Molecular and Cell Biology, Second Edition
How to Cite
Feldmann, H. (ed) (2012) Yeast Organellar Biogenesis and Function, in Yeast: Molecular and Cell Biology, Second Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527659180.ch11
Adolf Butenandt Institute, Molecular Biology, Ludwig-Maximilians-Universität M¨nchen, Schillerstr. 44, 80336 M¨nchen, Germany
Ludwig-Thoma-Strasse 22B, 85232 Bergkirchen, Germany
- Published Online: 26 SEP 2012
- Published Print: 22 AUG 2012
Print ISBN: 9783527332526
Online ISBN: 9783527659180
• This chapter is devoted to the two most important organelles – the mitochondria and the peroxisomes. Yeast mitochondria as cytoplasmic entities, responsible for extrachromosomal inheritance, were disclosed in the middle of the last century, but since then a multitude of genetic and biochemical studies have contributed a wealth of information on cellular activities pertinent to mitochondria and essential for life. In particular, yeast mitochondria offered a suitable and very convenient model system to follow the details of the import of nuclear-encoded proteins, resulting in the deciphering of the subtleties of how different types of proteins are directed to distinct locations in the mitochondrion – delivery to the outer membrane, the intermembrane space, the inner membrane, or the matrix. Moreover, quality control mechanisms were encountered to balance protein import in order to avoid an accumulation of excess or misfolded proteins. Components mediating fission and fusion of mitochondria were described. It is estimated that over 1000 nuclear-encoded yeast genes participate in regulating mitochondrial biogenesis, while only a handful of mitochondrially synthesized proteins complement the population of mitochondrial components.
• Over the years, the components constituting the yeast peroxisome have been considered to be controlling the import of cytosolic compounds and to be responsible for peroxisome proliferation. To date, more than 50 of such proteins have been disclosed, 32 of them belonging to the group of the so-called peroxins (Pex proteins). This knowledge has helped explain malfunctions of these two organelles in yeast and, importantly, their relationship with various human diseases.