13. Disease Genes in Yeast

  1. Prof. Dr. Horst Feldmann1,2

Published Online: 26 SEP 2012

DOI: 10.1002/9783527659180.ch13

Yeast: Molecular and Cell Biology, Second Edition

Yeast: Molecular and Cell Biology, Second Edition

How to Cite

Feldmann, H. (ed) (2012) Disease Genes in Yeast, in Yeast: Molecular and Cell Biology, Second Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527659180.ch13

Editor Information

  1. 1

    Adolf Butenandt Institute, Molecular Biology, Ludwig-Maximilians-Universität M¨nchen, Schillerstr. 44, 80336 M¨nchen, Germany

  2. 2

    Ludwig-Thoma-Strasse 22B, 85232 Bergkirchen, Germany

Publication History

  1. Published Online: 26 SEP 2012
  2. Published Print: 22 AUG 2012

ISBN Information

Print ISBN: 9783527332526

Online ISBN: 9783527659180

SEARCH

Keywords:

  • diseasegenes in yeast;
  • trinucleotiderepeats;
  • neurodegenerative diseases;
  • aging;
  • age-related disorders;
  • mitochondrial diseases

Summary

• Whereas in previous chapters the invaluable aid of yeast as a model in identifying and investigating human disease genes was stressed, this chapter summarizes some of the relevant approaches. The justification lies in the fact that many basic functions have been preserved through evolution from yeast to humans. Examples have been mentioned for genes involved in NER and numerous genes for transporters, such as ABC transporters, metal transporters, or channel proteins, and have not to be repeated here; instead, major attention focuses on neurodegenerative disorders (such as Huntington's, Parkinson's, and Alzheimer's diseases, as well as other human neuropathies, often induced by trinucleotide repeats), for which yeast has offered useful research models. Similarly, human mitochondrial disorders have found their counterparts in yeast mitochondrial defects.

• Aging phenomena observed and studied in yeast present ideas about which traits could affect human aging.