7. Yeast Growth and the Yeast Cell Cycle

  1. Prof. Dr. Horst Feldmann1,2

Published Online: 26 SEP 2012

DOI: 10.1002/9783527659180.ch7

Yeast: Molecular and Cell Biology, Second Edition

Yeast: Molecular and Cell Biology, Second Edition

How to Cite

Feldmann, H. (ed) (2012) Yeast Growth and the Yeast Cell Cycle, in Yeast: Molecular and Cell Biology, Second Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527659180.ch7

Editor Information

  1. 1

    Adolf Butenandt Institute, Molecular Biology, Ludwig-Maximilians-Universität M¨nchen, Schillerstr. 44, 80336 M¨nchen, Germany

  2. 2

    Ludwig-Thoma-Strasse 22B, 85232 Bergkirchen, Germany

Publication History

  1. Published Online: 26 SEP 2012
  2. Published Print: 22 AUG 2012

ISBN Information

Print ISBN: 9783527332526

Online ISBN: 9783527659180



  • yeastgrowth;
  • yeast cell cycle;
  • modes of propagation;
  • cell cycle;
  • meiosis


• Cell growth and propagation are two sides of the same coin. When yeast cells have reached a critical size during vegetative growth under appropriate environmental conditions, they are prepared to divide and generate progeny by budding. The single steps of this process are subject to control by the mitotic cell cycle, which invokes periodic events to induce and regulate chromosome duplication, carefully avoiding multiple duplications as well as checking possible DNA damage and taking measures for DNA repair. Concomitantly, all morphogenetic changes that are connected to proliferation have to be organized in an orderly programmed interplay. All of these important processes have been intensely investigated in S. cerevisiae. In fact, research in budding yeast growth and cell cycle opened perspectives on many processes that turned out to be basically the same in higher eukaryotes. Admittedly, our present knowledge on decisive aspects of the cell cycle would not have come true without important complementary findings in other systems.

• Our discourse starts with a description of the budding process, including cell polarity and bud site selection, along with their regulation, as well as dynamics of morphogenic structures such as the bud neck, the spindle, and the SPB. Briefly, morphogenic differences toward mating, the sexual mode of yeast reproduction, filamentous growth, and cell death are discussed.

• A larger part of this chapter is devoted to dynamics and regulation of the cell cycle, introducing the cyclins and the CDK activities, and focusing on their regulation and interplay. Since most aspects of DNA replication during the S phase have been presented in Chapter 5, we concentrate here on the pronounced events occurring during mitosis: cohesion of sister chromatids, structure and assembly of the spindle, and the significance of the spindle assembly checkpoint, steps during chromosome segregation, and exit from mitosis.

• A final part briefly touches on chromosome behavior in meiosis, determining the life cycle of sexual reproduction, which in yeast follows the conjugation of partners at mating and ends in the production of (normally) four haploid spores. In meiosis there is one round of chromosome duplication, but in contrast to mitosis, there are two successive nuclear divisions. To allow for exchange of genetic material between the two partners, cross-overs of the parental chromosomes are invoked before meiosis I. We describe the regulation of the meiotic events, stressing the relevance of checkpoints.