8. The Membrane as a Novel Target Site for Antibiotics to Kill Persisting Bacterial Pathogens

  1. Claudio O. Gualerzi,
  2. Letizia Brandi,
  3. Attilio Fabbretti and
  4. Cynthia L. Pon
  1. Xiaoqian Wu and
  2. Julian G. Hurdle

Published Online: 4 OCT 2013

DOI: 10.1002/9783527659685.ch8

Antibiotics: Targets, Mechanisms and Resistance

Antibiotics: Targets, Mechanisms and Resistance

How to Cite

Wu, X. and Hurdle, J. G. (2013) The Membrane as a Novel Target Site for Antibiotics to Kill Persisting Bacterial Pathogens, in Antibiotics: Targets, Mechanisms and Resistance (eds C. O. Gualerzi, L. Brandi, A. Fabbretti and C. L. Pon), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527659685.ch8

Editor Information

  1. Laboratory of Genetics, Department of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy

Author Information

  1. University of Texas at Arlington, Department of Biology, Life Sciences Building, Room 337, 501 South Nedderman Drive, Arlington, TX 76019 USA

Publication History

  1. Published Online: 4 OCT 2013
  2. Published Print: 23 OCT 2013

ISBN Information

Print ISBN: 9783527333059

Online ISBN: 9783527659685

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Keywords:

  • membrane-active;
  • antibiotics;
  • bactericidal activity;
  • biofilms;
  • tuberculosis

Summary

Since the discovery of penicillin, the ability to treat dormant bacterial infections with most chemotherapeutic agents has always been an enormous challenge. In these infections, bacteria are metabolically inactive and are often not killed by bactericidal agents or require protracted treatments. Within the past decade, the clinical advent of daptomycin, lipoglycopeptides, and other molecules with membrane-active properties have shown that targeting the membrane could be an approach to treat dormant infections. This emerging paradigm is the focus of this chapter, where we describe examples of these agents, their modes of actions and challenges that affect their clinical development.