7. CuAAC: The Quintessential Click Reaction

  1. Prof. Dr. Kuiling Ding and
  2. Prof. Dr. Li-Xin Dai
  1. Valery V. Fokin1 and
  2. Krzysztof Matyjaszewski2

Published Online: 23 AUG 2012

DOI: 10.1002/9783527664801.ch7

Organic Chemistry - Breakthroughs and Perspectives

Organic Chemistry - Breakthroughs and Perspectives

How to Cite

Fokin, V. V. and Matyjaszewski, K. (2012) CuAAC: The Quintessential Click Reaction, in Organic Chemistry - Breakthroughs and Perspectives (eds K. Ding and L.-X. Dai), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527664801.ch7

Editor Information

  1. Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, 345 Ling Ling Road, Shanghai 200032, China

Author Information

  1. 1

    The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

  2. 2

    Carnegie Mellon University, Department of Chemistry, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA

Publication History

  1. Published Online: 23 AUG 2012
  2. Published Print: 8 AUG 2012

ISBN Information

Print ISBN: 9783527333776

Online ISBN: 9783527664801

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Keywords:

  • click reaction;
  • CuAAC;
  • copper-catalyzed azide—alkyne cycloaddition;
  • azide-alkyne cycloaddition;
  • 1-iodoalkynes;
  • sulfonyl azides

Summary

This chapter contains sections titled:

  • Introduction

  • Azide–Alkyne Cycloaddition: the Basics

  • CuAAC: Catalysts and Ligands

  • Mechanistic Aspects of the CuAAC

  • Reactions of 1-Iodoalkynes

  • Examples of Application of the CuAAC Reaction

  • Reactions of Sulfonyl Azides

  • Outlook/Perspective

  • Acknowledgments

  • References

  • Comment 1

  • References