12. Bioactive Compounds from Marine Actinomycetes

  1. Se-Kwon Kim
  1. Ana M. Íñiguez-Martínez1,
  2. Graciela Guerra-Rivas2,
  3. Nahara E. Ayala-Sánchez3 and
  4. Irma E. Soria-Mercado2

Published Online: 8 JUL 2013

DOI: 10.1002/9783527665259.ch12

Marine Microbiology: Bioactive Compounds and Biotechnological Applications

Marine Microbiology: Bioactive Compounds and Biotechnological Applications

How to Cite

Íñiguez-Martínez, A. M., Guerra-Rivas, G., Ayala-Sánchez, N. E. and Soria-Mercado, I. E. (2013) Bioactive Compounds from Marine Actinomycetes, in Marine Microbiology: Bioactive Compounds and Biotechnological Applications (ed S.-K. Kim), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527665259.ch12

Editor Information

  1. Pukyong National University, Marine Bioprocess Research Center Daeyeon-Dong, Nam-Gu 599-1, Busan 608-737, Republic of Korea

Author Information

  1. 1

    Universidad de Guadalajara, Centro Universitario de la Costa, Av. Universidad de Guadalajara No. 203, Puerto Vallarta, Jal., 48280, Mexico

  2. 2

    Universidad Autónoma de Baja California, Facultad de Ciencias Marinas, Km. 103 Tijuana-Ensenada, Highway, Ensenada, BC, 22830, Mexico

  3. 3

    Universidad Autónoma de Baja California, Facultad de Ciencias, Km. 103 Tijuana-Ensenada, Highway, Ensenada, BC, 22830, Mexico

Publication History

  1. Published Online: 8 JUL 2013
  2. Published Print: 14 AUG 2013

ISBN Information

Print ISBN: 9783527333271

Online ISBN: 9783527665259

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Keywords:

  • actinomycetes;
  • antibiotic activity;
  • cytotoxic effect;
  • marine bacteria;
  • secondary metabolites

Summary

The order Actinomycetales is the most known prolific bacterial source of structurally diverse secondary metabolites. Academic and pharmaceutical researchers have been working on soil-derived actinomycetes since 55 years and more than 15 000 bioactive molecules are produced from these microbes, with many of them being used as drugs even today. The belief that actinomycetes isolated from marine sources were largely of terrestrial origin and existed in the ocean as metabolically inactive spores has been recently discarded, since phylogenetic analyses of their 16S rRNA genes indicate that many of these strains belong to a new taxa widely distributed in ocean sediments, including some that appear to be unique with proved antitumor effects. They also have metabolic and physiological capability of producing compounds with interesting pharmacological properties that have not been observed in terrestrial microorganisms. To date, actinomycetes are the most economically and biotechnologically valuable marine prokaryotes examined. However, their diversity remains relatively unexplored. Novel culturing methods and sampling techniques used to gain access to unknown environments will allow us to discover the fascinating world of novel bioactive secondary metabolites from microbial sources.