8. Strategies for Cofactor Regeneration in Biocatalyzed Reductions

  1. Elisabetta Brenna
  1. Selin Kara,
  2. Joerg H. Schrittwieser and
  3. Frank Hollmann

Published Online: 30 AUG 2013

DOI: 10.1002/9783527665785.ch08

Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions

Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions

How to Cite

Kara, S., Schrittwieser, J. H. and Hollmann, F. (2013) Strategies for Cofactor Regeneration in Biocatalyzed Reductions, in Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions (ed E. Brenna), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527665785.ch08

Editor Information

  1. Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy

Author Information

  1. Delft University of Technology, Department of Biotechnology, Julianalaan 136, 2628BL, Delft, The Netherlands

Publication History

  1. Published Online: 30 AUG 2013
  2. Published Print: 23 OCT 2013

ISBN Information

Print ISBN: 9783527333875

Online ISBN: 9783527665785

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Keywords:

  • biocatalysis;
  • cofactor regeneration;
  • dehydrogenase;
  • reduction reaction;
  • regeneration reaction;
  • stoichiometric reductant

Summary

This chapter contains sections titled:

  • Introduction: NAD(P)H as the Universal Reductant in Reduction Biocatalysis

  • The Most Relevant Cofactor Regeneration Approaches – and How to Choose the Most Suitable One

  • Coupling the Reduction Reaction to a Regeneration Reaction Producing a Valuable Compound

  • Avoiding NAD(P)H: Does It Also Mean Avoiding the Challenge?

  • Conclusions