5. Radical Reactions in Domino Processes

  1. Lutz F. Tietze
  1. Guanghui An1 and
  2. Guigen Li2

Published Online: 27 DEC 2013

DOI: 10.1002/9783527671304.ch5

Domino Reactions: Concepts for Efficient Organic Synthesis

Domino Reactions: Concepts for Efficient Organic Synthesis

How to Cite

An, G. and Li, G. (2014) Radical Reactions in Domino Processes, in Domino Reactions: Concepts for Efficient Organic Synthesis (ed L. F. Tietze), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527671304.ch5

Editor Information

  1. Georg-August University, Institute of Organic and Biomolecular Chemistry, Tammannstr. 2, 37077 Göttingen, Germany

Author Information

  1. 1

    Texas Tech University, Department of Chemistry and Biochemistry, Street Boston and Broadway, Lubbock, TX 79409-1061, USA

  2. 2

    Nanjing University, Institute of Chemistry & BioMedical Sciences, 22 Hankou Road, Nanjing, 210093, P. R. China

Publication History

  1. Published Online: 27 DEC 2013
  2. Published Print: 10 JAN 2014

ISBN Information

Print ISBN: 9783527334322

Online ISBN: 9783527671304



  • domino process;
  • radical cation salt;
  • tetracyclic;
  • samarium diiodide;
  • quaternary carbon centers;
  • heterocyclic


Domino processes involving radical reactions have attracted a lot of attention due to their intrinsic elegance and the construction of a broad and sometimes unique array of molecular architectures they allow in a single step. This chapter focuses on the recent progress in the design and development of this field. The first part is devoted to radical/cation domino processes; the second part provides the latest examples for the radical/anionic domino processes. The next two parts cover domino processes involving both radical/radical and radical/pericyclic reactions. Finally, the last part focuses on asymmetric version of radical domino reactions involving both chiral auxiliary and chiral catalysts.