21. RNA Aptamer Design

  1. Gisbert Schneider
  1. Cindy Meyer1,
  2. Ulrich Hahn2 and
  3. Andrew E. Torda3

Published Online: 11 OCT 2013

DOI: 10.1002/9783527677016.ch21

De novo Molecular Design

De novo Molecular Design

How to Cite

Meyer, C., Hahn, U. and Torda, A. E. (2013) RNA Aptamer Design, in De novo Molecular Design (ed G. Schneider), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527677016.ch21

Editor Information

  1. ETH Zürich, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland

Author Information

  1. 1

    The Rockefeller University, Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, 1230 York Ave, New York, NY 10065, USA

  2. 2

    University of Hamburg, MIN-Faculty, Chemistry Dept, Institute for Biochemistry and Molecular Biology, Martin-Luther-King Platz 6, D-20146 Hamburg, Germany

  3. 3

    University of Hamburg, Centre for Bioinformatics, Bundesstrasse 43, D-20146, Hamburg, Germany

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 13 NOV 2013

ISBN Information

Print ISBN: 9783527334612

Online ISBN: 9783527677016

SEARCH

Keywords:

  • aptamer;
  • selex;
  • RNA design

Summary

Aptamers are oligonucleotides that bind ligands–sometimes strongly and sometimes very specifically. They are, or will be, the basis of therapeutics, assays, and sensors. We consider how these molecules are designed and selected, and to what extent computational methods have helped or might help.