17. Enzymatic Generation of Sialoconjugate Diversity

  1. Sergio Riva2 and
  2. Wolf-Dieter Fessner3
  1. Wolf-Dieter Fessner,
  2. Ning He,
  3. Dong Yi,
  4. Peter Unruh and
  5. Marion Knorst

Published Online: 27 JUN 2014

DOI: 10.1002/9783527682492.ch17

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

How to Cite

Fessner, W.-D., He, N., Yi, D., Unruh, P. and Knorst, M. (2014) Enzymatic Generation of Sialoconjugate Diversity, in Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions (eds S. Riva and W.-D. Fessner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527682492.ch17

Editor Information

  1. 2

    Istituto di Chimica del, Riconoscimento Molecolare, C. N. R., Via Mario Bianco 9, 20131 Milano, Italy

  2. 3

    Technische Universität, Darmstadt, Department of Organic, Chemistry and Biochemistry, Petersenstr. 22, D-64287 Darmstadt, Germany

Author Information

  1. Technische Universität Darmstadt, Department of Organic Chemistry and Biochemistry, Petersenstr. 22, D-64287, Darmstadt, Germany

Publication History

  1. Published Online: 27 JUN 2014
  2. Published Print: 23 JUL 2014

ISBN Information

Print ISBN: 9783527335220

Online ISBN: 9783527682492

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Keywords:

  • Sialic acid;
  • glycoconjugate;
  • oligosaccharides;
  • neuraminic acid aldolase;
  • sialyl transfer

Summary

Sialic acid conjugates represent one of the most important constituents of cell-surface glycoconjugates in biological systems. A large variety of sialic acid derivatives are observed stemming from postsynthetic modifications for which the physiological role is yet unknown. This overview highlights the requirements for enzyme promiscuity and applicable strategies for in vitro synthesis of variously modified sialoconjugates for studies in glycobiology.