3. Monooxygenase-Catalyzed Redox Cascade Biotransformations

  1. Sergio Riva2 and
  2. Wolf-Dieter Fessner3
  1. Florian Rudroff and
  2. Marko D. Mihovilovic

Published Online: 27 JUN 2014

DOI: 10.1002/9783527682492.ch3

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

How to Cite

Rudroff, F. and Mihovilovic, M. D. (2014) Monooxygenase-Catalyzed Redox Cascade Biotransformations, in Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions (eds S. Riva and W.-D. Fessner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527682492.ch3

Editor Information

  1. 2

    Istituto di Chimica del, Riconoscimento Molecolare, C. N. R., Via Mario Bianco 9, 20131 Milano, Italy

  2. 3

    Technische Universität, Darmstadt, Department of Organic, Chemistry and Biochemistry, Petersenstr. 22, D-64287 Darmstadt, Germany

Author Information

  1. Vienna University of Technology, Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060, Vienna, Austria

Publication History

  1. Published Online: 27 JUN 2014
  2. Published Print: 23 JUL 2014

ISBN Information

Print ISBN: 9783527335220

Online ISBN: 9783527682492

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Keywords:

  • monooxygenase;
  • biocatalysis;
  • oxyfunctionalization;
  • cascade process;
  • cofactor recycling

Summary

In this chapter, we present a historical overview on the development, investigation, and application of oxygen-activating enzymes, focusing on monooxygenases, in the context of cascade reactions. In the past decades, this enzyme class was used very successfully, particularly in the synthesis of valuable natural and bioactive compounds. Starting from the very simple case of cofactor regeneration by a complementary reductase, via the investigation of complex chemoenzymatic processes, to ultimately providing a future perspective with an artificial minipathway composed of four consecutive redox reactions in a living organism, the potential as well as the current limitations of monooxygenases will be outlined in the field of applied biocatalysis.