4. Biocatalytic Redox Cascades Involving ω-Transaminases

  1. Sergio Riva2 and
  2. Wolf-Dieter Fessner3
  1. Robert C. Simon,
  2. Nina Richter and
  3. Wolfgang Kroutil

Published Online: 27 JUN 2014

DOI: 10.1002/9783527682492.ch4

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

How to Cite

Simon, R. C., Richter, N. and Kroutil, W. (2014) Biocatalytic Redox Cascades Involving ω-Transaminases, in Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions (eds S. Riva and W.-D. Fessner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527682492.ch4

Editor Information

  1. 2

    Istituto di Chimica del, Riconoscimento Molecolare, C. N. R., Via Mario Bianco 9, 20131 Milano, Italy

  2. 3

    Technische Universität, Darmstadt, Department of Organic, Chemistry and Biochemistry, Petersenstr. 22, D-64287 Darmstadt, Germany

Author Information

  1. University of Graz, Institute of Chemistry, Heinrichstr. 28, 8010, Graz, Austria

Publication History

  1. Published Online: 27 JUN 2014
  2. Published Print: 23 JUL 2014

ISBN Information

Print ISBN: 9783527335220

Online ISBN: 9783527682492

SEARCH

Keywords:

  • Reductive amination;
  • omega-transaminase;
  • redox-neutral;
  • asymmetric synthesis;
  • deracemization;
  • kinetic resolution

Summary

The combination of transaminases with other enzymes provides a new level of efficient functional group interconversions that is difficult or impossible to achieve by pure chemical means. This chapter describes linear cascades, for example, for the amination of alcohols or C–H, cascades involving spontaneous steps or steps catalyzed by lyases or hydrolases, and deracemization cascades.