6. Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates

  1. Sergio Riva2 and
  2. Wolf-Dieter Fessner3
  1. Ruben R. Rosencrantz,
  2. Bastian Lange and
  3. Lothar Elling

Published Online: 27 JUN 2014

DOI: 10.1002/9783527682492.ch6

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

How to Cite

Rosencrantz, R. R., Lange, B. and Elling, L. (2014) Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates, in Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions (eds S. Riva and W.-D. Fessner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527682492.ch6

Editor Information

  1. 2

    Istituto di Chimica del, Riconoscimento Molecolare, C. N. R., Via Mario Bianco 9, 20131 Milano, Italy

  2. 3

    Technische Universität, Darmstadt, Department of Organic, Chemistry and Biochemistry, Petersenstr. 22, D-64287 Darmstadt, Germany

Author Information

  1. RWTH Aachen University, Department of Biotechnology and Helmholtz-Institute for Biomedical Engineering, Worringer Weg 1, 52056, Aachen, Germany

Publication History

  1. Published Online: 27 JUN 2014
  2. Published Print: 23 JUL 2014

ISBN Information

Print ISBN: 9783527335220

Online ISBN: 9783527682492

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Keywords:

  • Glycans;
  • chemoenzymatic synthesis;
  • sequential-synthesis;
  • one-pot synthesis;
  • glycosyltransferase;
  • glycoconjugates;
  • nucleotide sugar

Summary

Glycoconjugates are involved in numerous biologic interactions among them, such as disparate functions as the development of multicellular organisms, tumor invasion, and metastasis and pathogen-host interactions. To fulfill such diverse roles, they belong to nature's most structurally and functionally diverse and complex structures. Their potential for biomedical applications is high – but their synthesis is likewise demanding. Cascade reactions are a proven tool to synthesize complex glycoconjugates in either a one-pot, a sequential, or convergent synthesis approach. We critically introduce available enzymatic tools, discuss reaction approaches, and show recent prominent examples of each reaction type.