9. Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode

  1. Sergio Riva2 and
  2. Wolf-Dieter Fessner3
  1. Zoltán Boros,
  2. Gábor Hornyánszky,
  3. József Nagy and
  4. László Poppe

Published Online: 27 JUN 2014

DOI: 10.1002/9783527682492.ch9

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions

How to Cite

Boros, Z., Hornyánszky, G., Nagy, J. and Poppe, L. (2014) Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode, in Cascade Biocatalysis : Integrating Stereoselective and Environmentally Friendly Reactions (eds S. Riva and W.-D. Fessner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527682492.ch9

Editor Information

  1. 2

    Istituto di Chimica del, Riconoscimento Molecolare, C. N. R., Via Mario Bianco 9, 20131 Milano, Italy

  2. 3

    Technische Universität, Darmstadt, Department of Organic, Chemistry and Biochemistry, Petersenstr. 22, D-64287 Darmstadt, Germany

Author Information

  1. Budapest University of Technology and Economics, Department for Organic Chemistry and Technology, Szt Gellért tér 4, H-1111, Budapest, Hungary

Publication History

  1. Published Online: 27 JUN 2014
  2. Published Print: 23 JUL 2014

ISBN Information

Print ISBN: 9783527335220

Online ISBN: 9783527682492

SEARCH

Keywords:

  • Continuous-flow reaction;
  • microreactor;
  • strereoselective biotransformation;
  • enzyme immobilization;
  • hydrolase

Summary

This chapter demonstrates with a wide range of examples the high potential of continuous-flow techniques for stereoselective biotransformations catalyzed by enzymes, especially hydrolases. Benefits of the various reactor setups are discussed, for example, the continuous flow packed bed reactors can enhance the productivity of enzyme-catalyzed processes or miniaturized continuous flow systems allow fast high-throughput screenings. Continuous flow microreactor systems enabled integration of enzyme-catalysis with chemical steps (e.g., in dynamic kinetic resolutions) or with continuous extraction or performing multienzyme-catalyzed multistep biotransformations. Thus, the potential of continuous-flow microreactor systems with immobilized biocatalysts is demonstrated as process development tool for stereoselective biotransformations.