The Importance of β-Alanine for Recognition of the Minor Groove of DNA

  1. Prof. Gerhard Quinkert2 and
  2. Dr. M. Volkan Kisakürek3
  1. Peter B. Dervan and
  2. Adam R. Urbach

Published Online: 3 MAY 2007

DOI: 10.1002/9783906390451.ch9

Essays in Contemporary Chemistry: From Molecular Structure towards Biology

Essays in Contemporary Chemistry: From Molecular Structure towards Biology

How to Cite

Dervan, P. B. and Urbach, A. R. (2001) The Importance of β-Alanine for Recognition of the Minor Groove of DNA, in Essays in Contemporary Chemistry: From Molecular Structure towards Biology (eds G. Quinkert and M. V. Kisakürek), Verlag Helvetica Chimica Acta, Zürich. doi: 10.1002/9783906390451.ch9

Editor Information

  1. 2

    Institut für Organische Chemie, Johann Wolfgang Goethe-Universität, Marie Curie-Str. 11, D-60439 Frankfurt am Main, Germany

  2. 3

    Verlag Helvetica Chimica Acta, Hofwiesenstrasse 26, Postfach, CH-8042 Zürich, Switzerland

Author Information

  1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, USA

Publication History

  1. Published Online: 3 MAY 2007
  2. Published Print: 13 SEP 2001

ISBN Information

Print ISBN: 9783906390284

Online ISBN: 9783906390451

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Keywords:

  • recognition of the minor groove of DNA, beta;-alanine

Summary

It is now well-recognized that there are two global motifs for targeting the minor groove of DNA based on analogs of the N-methylpyrrole-carboxamide ring of the natural product distamycin. There exist 1:1 and 2:1 stoichiometries with quite different rules of recognition and specificity. This ambiguity of sequence targeting depending on stoichiometry raises a serious design issue for the DNA recognition field.