Response to Intervention (RTI) has the potential to have a positive impact on adolescent literacy by requiring content-area teachers to provide Tier 1 literacy instruction. This commentary suggests that content-area teachers can help their students improve their content knowledge and literacy skills by providing discipline-specific strategy instruction in their classes. To do this, content-area teachers should have a clear understanding of how literacy is used in their discipline and demonstrate those processes for their students. Moreover, content-area teachers should provide students with more opportunities to read grade-appropriate texts, differentiate reading materials, and assess literacy progress. Furthermore, content-area teachers should provide literacy coaches with classroom texts and topics so that Tier-2 interventions can be coordinated with classroom teaching. These changes in content-area teaching could make a difference in the literacy achievement of students.