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A continuing stream of advances in the neurosciences has dramatically altered long-held beliefs about how the brain works and what goes wrong in disease. The pace at which these advances are being translated into clinical neurology is accelerating rapidly, and it has become progressively more difficult for clinicians to keep abreast of them. The pace and breadth of change has also increased the imperative to make access to new clinically relevant information open and immediately accessible to everyone. To help meet this need the American Neurological Association (ANA) is pleased to announce a new open access journal, the Annals of Clinical and Translational Neurology (ACTN).

ACTN will be broad in its scope and international in its reach. The peer review process will be rigorous to assure the prestige of the journal. As implied by its name, ACTN particularly seeks to expand the portfolio of clinical and translational studies published under the auspices of the ANA. ACTN will publish original research and scholarly reviews focused on understanding the mechanisms and treatments of diseases of the nervous system, and it seeks to become a preferred venue for publishing important clinical trials. Its scope also includes topics of particular significance in neurologic education as well as other topics of interest to the clinical neuroscience community. In addition to manuscripts from established investigators, ACTN will welcome scholarly work, points-of-view, and case studies from residents, fellows and medical students. As the flagship open access journal of the ANA, ACTN will provide a venue for the clinical neuroscience community that maintains rigor and substance.

ACTN will offer all of the best features of open access publishing. Within days of its acceptance, a manuscript can be read by anyone with internet access anywhere in the world, so the work can be widely and rapidly disseminated. As an online journal, ACTN will not be restricted by page limitations and production costs. Therefore all relevant figures can be presented in full color, methodologies can be explained more fully, and the significance of the findings can be highlighted. Thus at a modest cost to the authors, it will greatly enhance their ability to convey the full implications of their work in a respected, peer-reviewed publication. Notably, funding agencies in some venues already require open access to publications emanating from research they have sponsored, and there is substantial public pressure for this to become a widespread requirement.

ACTN and the Annals of Neurology share the same publisher, John Wiley and Sons, as well as sponsorship by the ANA, and these sister journals will work closely together to assure the publication of scientifically meritorious manuscripts. They will have the same format for preparation of manuscripts, and there will be a close relationship between the two journals. After submission of a manuscript to one of the journals, some authors may be offered the option of having it transferred to the other journal along with any completed external reviews. This mechanism will spare authors the burden of reformatting the manuscript for submission to another journal, and the availability of reviews will expedite consideration by the second set of editors. At the present time the Annals of Neurology is only able to publish a minority of submitted manuscripts including many that receive very positive reviews, and review by a second set of editors should enable more of those papers to be published under the ANA imprint.

The editors of ACTN all share the goal of making the submission and peer–review process friendly, fair and constructive. We are specifically structured to provide authors a decision very quickly. Our aim is to convince you by our editorial processes and outstanding content that the Annals of Clinical and Translational Neurology is where you should be sending your research, particularly studies that focus on clinical and translational neuroscience. I am honored that I was offered the opportunity to be the founding Editor-in-Chief of ACTN, and I look forward to having you join us as readers and authors in this exciting venture.