Equally contributing authors.
Isoflurane suppresses early cortical activity
Article first published online: 20 NOV 2013
© 2013 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Annals of Clinical and Translational Neurology
Volume 1, Issue 1, pages 15–26, January 2014
How to Cite
Sitdikova, G., Zakharov, A., Janackova, S., Gerasimova, E., Lebedeva, J., Inacio, A. R., Zaynutdinova, D., Minlebaev, M., Holmes, G. L. and Khazipov, R. (2014), Isoflurane suppresses early cortical activity. Annals of Clinical and Translational Neurology, 1: 15–26. doi: 10.1002/acn3.16
- Issue published online: 22 JAN 2014
- Article first published online: 20 NOV 2013
- Manuscript Accepted: 30 SEP 2013
- Manuscript Revised: 29 SEP 2013
- Manuscript Received: 15 AUG 2013
- Agence Nationale de la Recherche. Grant Number: ANR-09-MNPS-006
- Government of the Russian Federation. Grant Number: 11.G34.31.0075
- Fondation pour la Recherche Medicale. Grant Number: DEQ20110421301
Figure S1. Age dependence in the effects of isoflurane (1.5–2%) on SEP amplitude (top) and L4 MUA density during SEP (bottom). Each pair corresponds to an individual rat; circles with error bars correspond to the group averages at P2–7, P8–15, and P16–69. On the right are shown probability value maps for the comparisons between the activity in control conditions and under isoflurane in three age groups. Within each age group P-values were obtained from paired data comparisons.
Figure S2. Characteristics of the responses evoked by stimuli in different sensory modalities in an adult rat under isoflurane anesthesia. Delays of the responses evoked by sensory stimuli in different modalities in an adult rat (P30) under 2% isoflurane anesthesia. Below, P-value map for the comparisons of MUA times relative to the population spikes as illustrated in main Figure 6C.
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