Motor threshold predicts working memory performance in healthy humans
Article first published online: 6 DEC 2013
© 2013 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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Annals of Clinical and Translational Neurology
Volume 1, Issue 1, pages 69–73, January 2014
How to Cite
Schicktanz, N., Schwegler, K., Fastenrath, M., Spalek, K., Milnik, A., Papassotiropoulos, A., Nyffeler, T. and de Quervain, D. J.-F. (2014), Motor threshold predicts working memory performance in healthy humans. Annals of Clinical and Translational Neurology, 1: 69–73. doi: 10.1002/acn3.22
- Issue published online: 22 JAN 2014
- Article first published online: 6 DEC 2013
- Manuscript Accepted: 7 NOV 2013
- Manuscript Revised: 24 OCT 2013
- Manuscript Received: 5 AUG 2013
- UNISCIENTIA STIFTUNG
Cognitive functions, such as working memory, depend on neuronal excitability in a distributed network of cortical regions. It is not known, however, if interindividual differences in cortical excitability are related to differences in working memory performance. In the present transcranial magnetic stimulation study, which included 188 healthy young subjects, we show that participants with lower resting motor threshold, which is related to higher corticospinal excitability, had increased 2-back working memory performance. The findings may help to better understand the link between cortical excitability and cognitive functions and may also have important clinical implications with regard to conditions of altered cortical excitability.