Preventable infections in children with leukodystrophy

Authors

  • Holly M. Anderson,

    1. School of Medicine, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
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  • Jacob Wilkes,

    1. Intermountain Healthcare, Salt Lake City, Utah
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  • Ernest Kent Korgenski,

    1. Intermountain Healthcare, Salt Lake City, Utah
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  • Michael A. Pulsipher,

    1. Division of Hematology and Hematological Malignancies, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
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  • Anne J. Blaschke,

    1. Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
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  • Adam L. Hersh,

    1. Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
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  • Rajendu Srivastava,

    1. Division of Inpatient Medicine, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
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  • Joshua L. Bonkowsky

    Corresponding author
    1. Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
    2. Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah
    • Correspondence

      Joshua L. Bonkowsky, Department of Pediatrics and of Neurology, University of Utah School of Medicine, 295 Chipeta Way/Williams Building, Salt Lake City, UT 84108.

      Tel.: 801-581-6756; Fax: 801-581-4233

      E-mail: joshua.bonkowsky@hsc.utah.edu

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Abstract

Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (preexisting indwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection-related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio [OR] 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.

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