Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis
Article first published online: 3 JUN 2014
© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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Annals of Clinical and Translational Neurology
Volume 1, Issue 6, pages 423–432, June 2014
How to Cite
Bonnier, G., Roche, A., Romascano, D., Simioni, S., Meskaldji, D., Rotzinger, D., Lin, Y.-C., Menegaz, G., Schluep, M., Du Pasquier, R., Sumpf, T. J., Frahm, J., Thiran, J.-P., Krueger, G. and Granziera, C. (2014), Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis. Annals of Clinical and Translational Neurology, 1: 423–432. doi: 10.1002/acn3.68
- Issue published online: 19 JUN 2014
- Article first published online: 3 JUN 2014
- Manuscript Accepted: 28 APR 2014
- Manuscript Revised: 27 MAR 2014
- Manuscript Received: 12 FEB 2014
- Swiss National Science Foundation. Grant Numbers: PZ00P3_131914/11, PP00P2-123438
- Swiss MS Society
- Societé Académique Vaudoise
In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients.
Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates.
Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: −4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R2 = 0.4), attention (P = 0.0005, Adj-R2 = 0.6), and disability (P = 0.03, Adj-R2 = 0.4).
Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical–radiological correlations in patients with minor deficits, as compared to conventional measures of disease.