We examined whether college-age video game players and musicians are better than controls at implicit sequence learning in the Alternating Serial Reaction Time Task. People learn to use subtle sequence regularities to respond more accurately and quickly to predictable versus non-predictable events. Although previous studies have shown experts' enhanced processing speed and perception, this is the first to demonstrate that people who regularly play video games or a musical instrument showed greater implicit sequence learning, suggesting that experience playing games or music may improve the efficiency with which people learn sequential regularities in the environment. Copyright © 2011 John Wiley & Sons, Ltd.