Dr. Charles-Schoeman has received consultant fees, speaking fees, and/or honoraria (less than $10,000) from Wyeth and a research grant (less than $10,000) from Amgen.
Systemic Lupus Erythematosus
Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus
Article first published online: 28 JAN 2010
Copyright © 2010 by the American College of Rheumatology
Arthritis Care & Research
Volume 62, Issue 2, pages 258–265, February 2010
How to Cite
Volkmann, E. R., Grossman, J. M., Sahakian, L. J., Skaggs, B. J., FitzGerald, J., Ragavendra, N., Charles-Schoeman, C., Chen, W., Gorn, A., Karpouzas, G., Weisman, M., Wallace, D. J., Hahn, B. H. and McMahon, M. (2010), Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus. Arthritis Care Res, 62: 258–265. doi: 10.1002/acr.20076
- Issue published online: 28 JAN 2010
- Article first published online: 28 JAN 2010
- Manuscript Accepted: 18 SEP 2009
- Manuscript Received: 13 APR 2009
- Lupus Research Institute
- Alliance for Lupus Research
- Kirkland Award
- Lupus Research Institute
- American College of Rheumatology Research and Education Foundation
- NIH. Grant Number: 1K23AR053864-01A1
- Arthritis Foundation
- Iris Cantor Women's Health Foundation
To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE).
A total of 242 SLE patients (all women) participated in this cross-sectional study from February 2004 to February 2008. Carotid plaque and intima-media thickness (IMT), antioxidant function of HDL, and traditional cardiac risk factors were measured. Physical activity was assessed from self-reports by calculating the metabolic equivalents (METS) per week and by the physical function domain of the Medical Outcomes Study Short Form 36 (SF-36). Data were analyzed using bivariate and multivariate regression analyses.
Number of METS per week spent performing strenuous exercise was negatively correlated with IMT (r = −0.4, P = 0.002) and number of plaques (r = −0.30, P = 0.0001). Physical function as assessed by the SF-36 was also negatively correlated with IMT (r = −0.14, P = 0.03) and number of plaques (r = −0.14, P = 0.04). In multivariate analyses, number of strenuous exercise METS was significantly associated with IMT (t = −2.2, P = 0.028) and number of plaques (t = −2.5, P = 0.014) when controlling for markers of SLE disease activity and damage, but not after controlling for traditional cardiac risk factors. Low physical activity, defined as <225 total METS per week, was associated with the presence of proinflammatory HDL (P = 0.03).
Low physical activity is associated with increased subclinical atherosclerosis and proinflammatory HDL in patients with SLE. Increased strenuous exercise may reduce the risk of atherosclerosis in SLE.