Drs. Benichou and Myers have stock ownership or options in Eli Lilly.
One-year change in radiographic joint space width in patients with unilateral joint space narrowing: Data from the osteoarthritis initiative
Article first published online: 23 FEB 2010
Copyright © 2010 by the American College of Rheumatology
Arthritis Care & Research
Volume 62, Issue 7, pages 924–931, July 2010
How to Cite
Benichou, O. D., Hunter, D. J., Nelson, D. R., Guermazi, A., Eckstein, F., Kwoh, K., Myers, S. L., Wirth, W. and Duryea, J. (2010), One-year change in radiographic joint space width in patients with unilateral joint space narrowing: Data from the osteoarthritis initiative. Arthritis Care Res, 62: 924–931. doi: 10.1002/acr.20149
- Issue published online: 29 JUN 2010
- Article first published online: 23 FEB 2010
- Manuscript Accepted: 9 FEB 2010
- Manuscript Received: 3 AUG 2009
- Osteoarthritis Initiative, a public-private partnership comprised of 5 contracts. Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Osteoarthritis Initiative Study Investigators
- Eli Lilly
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- Pfizer (private sector funding for the Osteoarthritis Initiative is managed by the Foundation for the NIH)
To examine the rate of joint space width (JSW) loss in both knees of patients with unilateral medial joint space narrowing (JSN) at baseline.
Cases were selected from a pool of 2,678 subjects enrolled in the Osteoarthritis Initiative cohort. Inclusion criteria for the present study were unilateral medial JSN, bilateral frequent knee pain, and body mass index (BMI) ≥25 kg/m2. Baseline and 1-year fixed flexion radiographs of both knees were read (blinded to time point) using an automated algorithm for minimum JSW and JSW at 4 fixed locations in the medial compartment.
Sixty-seven participants met the inclusion criteria: 43 women and 24 men, with mean ± SD age 60 ± 9 years and mean ± SD BMI 31 ± 4 kg/m2. Thirty-seven subjects (55%) had ≥1 definite tibiofemoral osteophyte. The average progression in no-JSN knees was comparable with that in JSN knees (approximately −0.2 mm/year). However, JSW change was more variable in no-JSN knees, resulting in standardized response means (SRMs; the mean/SD) of approximately −0.24 in no-JSN knees versus approximately −0.41 in JSN knees on average at the 4 fixed locations, and SRMs of −0.24 and −0.35, respectively, for minimum JSW. Young age and high BMI were associated with increased progression, especially in JSN knees.
JSN and no-JSN knees progressed at a comparable rate, but a wider distribution of JSW change in no-JSN knees resulted in a poorer sensitivity to change in these knees.