Contributions from the Field
Is a “false-positive” clinical diagnosis of knee osteoarthritis just the early diagnosis of pre–radiographic disease?
Article first published online: 9 APR 2010
Copyright © 2010 by the American College of Rheumatology
Arthritis Care & Research
Volume 62, Issue 10, pages 1502–1506, October 2010
How to Cite
Peat, G., Thomas, E., Duncan, R. and Wood, L. (2010), Is a “false-positive” clinical diagnosis of knee osteoarthritis just the early diagnosis of pre–radiographic disease?. Arthritis Care Res, 62: 1502–1506. doi: 10.1002/acr.20217
- Issue published online: 9 APR 2010
- Article first published online: 9 APR 2010
- Accepted manuscript online: 9 APR 2010 12:00AM EST
- Manuscript Accepted: 30 MAR 2010
- Manuscript Received: 4 DEC 2009
- Programme Grant from the Medical Research Council. Grant Number: G9900220
- Programme Grant from the Arthritis Research Campaign. Grant Number: 18174
- North Staffordshire Primary Care Research Consortium for National Health Service service support costs
In routine practice, diagnosis of knee osteoarthritis (OA) currently relies on the combination of conventional risk factors and the presence of cardinal signs and symptoms. However, their role in early diagnosis has received little attention compared with biomarker research.
Using data from 122 adults ages ≥50 years with knee pain but no definite radiographic OA, we tested whether the clinical diagnostic probability of OA, based on risk factors, signs, and symptoms, was associated with subsequent incidence of radiographic OA 3 years later.
Clinical diagnostic probability performed only modestly in discriminating incident radiographic knee OA (area under the receiver operating characteristic curve = 0.59, 95% confidence interval 0.49–0.70).
Improving the measurement of conventional markers and using study designs that test the ability of new biomarkers to add to or replace conventional markers are priorities for research in the early diagnosis of OA.