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Prevention of acute adverse events related to infliximab infusions in pediatric patients
Article first published online: 1 JUN 2010
DOI: 10.1002/acr.20246
Copyright © 2010 by the American College of Rheumatology
Additional Information
How to Cite
Lahdenne, P., Wikström, A. M., Aalto, K. and Kolho, K. L. (2010), Prevention of acute adverse events related to infliximab infusions in pediatric patients. Arthritis Care Res, 62: 785–790. doi: 10.1002/acr.20246
Publication History
- Issue published online: 1 JUN 2010
- Article first published online: 1 JUN 2010
- Manuscript Accepted: 2 NOV 2009
- Manuscript Received: 7 JUL 2009
Funded by
- Foundation for Pediatric Research, Finland
- Päivikki and Sakari Sohlberg Foundation, Finland
REFERENCES
- 1, , . Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: an open label study. Ann Rheum Dis 2003; 62: 245–7.
- 2, , , , , , et al, for the Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group. A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 2007; 56: 3096–106.
- 3, , , , , , et al. Tumor necrosis factor-α blocker in treatment of juvenile idiopathic arthritis-associated uveitis refractory to second-line agents: results of a multinational survey. J Rheumatol 2007; 34: 1146–50.
- 4, , , , . Infliximab and etanercept in the treatment of chronic uveitis associated with refractory juvenile idiopathic arthritis. Ann Rheum Dis 2007; 66: 548–50.
- 5, , , , , , et al. Efficacy and tolerance of infliximab in children and adolescents with Crohn's disease. Inflamm Bowel Dis 2004; 10: 745–50.
- 6, , , , , , et al. Efficacy of infliximab in pediatric Crohn's disease: a randomized multicenter open-label trial comparing scheduled to on demand maintenance therapy. Inflamm Bowel Dis 2009; 15: 388–94.
- 7, , , . Drug survival of the first and second course of anti-TNF agents in juvenile idiopathic arthritis. Ann Rheum Dis 2009; 68: 552–7.
- 8. Risks and benefits of biologic therapy for inflammatory bowel diseases. Gut 2007; 56: 725–32.
- 9, , , , , . Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006; 295: 2275–85.
- 10, , . Severe adverse reactions to infliximab therapy are common in young children with inflammatory bowel disease. Acta Paediatrica 2007; 96: 128–30.
- 11, , , . Non-response to infliximab may be due to innate neutralizing anti-tumour necrosis factor-α antibodies. Clin Exp Immunol 2008; 154: 325–31
- 12, , , , , , et al. The incidence and management of infusion reactions to infliximab: a large center experience. Am J Gastroenterol 2003; 98: 1315–24.Direct Link:
- 13, , , , , . Safety and steroid-sparing experience using infliximab for Crohn's disease at a pediatric inflammatory disease center. Am J Gastroenterol 2003; 98: 104–11.Direct Link:
- 14, , , , , , et al. Premedication and infusion reactions with infliximab: results from a pediatric inflammatory bowel disease consortium. Inflamm Bowel Dis 2005; 11: 442–6.
- 15
- 16, . Infusion reactions to infliximab in children and adolescents: frequency, outcome and a predictive model. Aliment Pharmacol Ther 2003; 17: 75–84.
- 17, , , , , , et al. Successful induction of tolerance to infliximab in patients with Crohn's disease and prior severe infusion reactions. Aliment Pharmacol Ther 2006; 24: 851–88.
- 18, , , , , , et al. Management of infusion reactions to infliximab in patients with rheumatoid arthritis or spondyloarthritis: experience from an immunotherapy unit of rheumatology. J Rheumatol 2006; 33: 1307–14.
- 19, , , , , , et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541–9.
- 20, , . Niacin-like reaction to infliximab infusion in systemic juvenile rheumatoid arthritis [letter]. J Rheumatol 2004; 31: 2529–30.
- 21
- 22, , , , , . Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. Br J Pharmacol 2008; 153: 760–8.
- 23. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem 2008; 15: 2173–91.
- 24, . Combination therapy of the chimeric monoclonal anti-tumor necrosis factor α antibody (infliximab) with methotrexate in patients with rheumatoid arthritis. Clin Exp Rheumatol 1999; 17: S73–7.
- 25, , , . Study of the tolerance of infliximab infusions with or without betamethasone premedication in patients with active rheumatoid arthritis. Ann Rheum Dis 2005; 64: 1647–9.
- 26, , , , . Low-dose glucocorticoid therapy decreases risk for treatment-limiting infusion reaction to infliximab in patients with rheumatoid arthritis. Ann Rheum Dis 2007; 66: 1462–66.
- 27, , , , , , et al. Safety and efficacy of readministration of infliximab after longterm continuous therapy and withdrawal in patients with ankylosing spondylitis. J Rheumatol 2007; 34: 510–5.

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