Osteoarthritis and Knee Pain
Does obesity predict knee pain over fourteen years in women, independently of radiographic changes?
Article first published online: 27 SEP 2011
Copyright © 2011 by the American College of Rheumatology
Arthritis Care & Research
Volume 63, Issue 10, pages 1398–1406, October 2011
How to Cite
Goulston, L. M., Kiran, A., Javaid, M. K., Soni, A., White, K. M., Hart, D. J., Spector, T. D. and Arden, N. K. (2011), Does obesity predict knee pain over fourteen years in women, independently of radiographic changes?. Arthritis Care Res, 63: 1398–1406. doi: 10.1002/acr.20546
- Issue published online: 27 SEP 2011
- Article first published online: 27 SEP 2011
- Accepted manuscript online: 7 JUL 2011 02:11PM EST
- Manuscript Accepted: 21 JUN 2011
- Manuscript Received: 11 NOV 2010
- National Institute for Health and Research Musculoskeletal Biomedical Research Unit, University of Oxford
- Arthritis Research UK
To examine longitudinal patterns in body mass index (BMI) over 14 years and its association with knee pain in the Chingford Study.
We studied a total of 594 women with BMI data from clinic visits at years (Y) 1, 5, 10, and 15. Knee pain at Y15 was assessed by questionnaire. Associations between BMI over 14 years and knee pain at Y15 were examined using logistic regression.
BMI significantly increased from Y1 to Y15 (P < 0.0005) with medians (interquartile ranges) of 24.5 kg/m2 (22.5–27.2 kg/m2) and 26.5 kg/m2 (23.9–30.1 kg/m2), respectively. At Y15, 45.1% of subjects had knee pain. A greater BMI at Y1 (odds ratio [OR] 1.34, 95% confidence interval [95% CI] 1.05–1.69), at Y15 (OR 1.34, 95% CI 1.10–1.61), and change in BMI over 15 years (OR 1.40, 95% CI 1.00–1.93) were significant predictors of knee pain at Y15 (P < 0.05). BMI change was associated with bilateral (OR 1.61, 95% CI 1.05–1.76, P = 0.024) but not unilateral knee pain (OR 1.22, 95% CI 0.73–1.76, P = 0.298). The association between BMI change and knee pain was independent of radiographic knee osteoarthritis (OA). The strength of association between BMI and knee pain at Y15 was similar during followup measurements.
Over 14 years, a higher BMI predicts knee pain at Y15 in women, independently of radiographic knee OA. When adjusted, the association was significant in bilateral, not unilateral, knee pain, suggesting alternative pathologic mechanisms may exist. The longitudinal effect of BMI on knee pain at Y15 is equally important at any time point, which may assist reducing the population burden of knee pain.