Dr. Bingham has received consultant fees (less than $10,000) from, serves as an investigator for, and has received research grant support from Procter & Gamble.
Identifying common trajectories of joint space narrowing over two years in knee osteoarthritis†
Version of Record online: 29 NOV 2011
Copyright © 2011 by the American College of Rheumatology
Arthritis Care & Research
Volume 63, Issue 12, pages 1722–1728, December 2011
How to Cite
Bartlett, S. J., Ling, S. M., Mayo, N. E., Scott, S. C. and Bingham, C. O. (2011), Identifying common trajectories of joint space narrowing over two years in knee osteoarthritis. Arthritis Care Res, 63: 1722–1728. doi: 10.1002/acr.20614
Unrestricted access to data was provided by Procter & Gamble. Drs. Bartlett and Bingham's work was supported by research grants from the Johns Hopkins Arthritis Center Discovery Fund.
- Issue online: 29 NOV 2011
- Version of Record online: 29 NOV 2011
- Accepted manuscript online: 8 SEP 2011 03:39PM EST
- Manuscript Accepted: 24 AUG 2011
- Manuscript Received: 28 MAR 2011
- Procter & Gamble
- Johns Hopkins Arthritis Center Discovery Fund
Little is known about the natural history of knee osteoarthritis (OA). We sought to identify common patterns of joint space narrowing (JSN) in well-characterized knee OA patients in the placebo arm of a 2-year international study.
We performed secondary data analyses of 622 adults ages 39–80 years in North America (n = 310) and Europe (n = 312) with symptomatic knee OA. Fluoroscopically positioned semiflexed anteroposterior radiographs were obtained at 0, 12, and 24 months. Group-based trajectory modeling was used to identify distinctive groups of individuals with similar trajectories of JSN, taking into account sex, age, and body mass index.
Seven groups were identified. Four exhibited joint space width (JSW) stability over 2 years representing the most common trajectory (71%), which was unrelated to initial JSW. Atypical courses included slow, rapid, and moderate progressors; most had significant JSN at study entry. Slow progressors (20%) had a mean JSN of 0.2 mm over 2 years. Only 2% of the sample demonstrated rapid JSN (2.1 mm), while 7% had JSN of 0.7 mm. Rapid progressors tended to be men, while slow and moderate progressors were older and heavier.
Most (70%) people with OA demonstrated no significant JSN over 2 years; 20% showed slow progression, 7% had moderate, and 2% had rapid JSN. Progressors tended to have less JSW at study entry and were older and heavier; rapid progressors were more likely to be men. Understanding common patterns of the course of knee OA may offer new opportunities to target those at greatest risk of disability.