This article was prepared using an Osteoarthritis Initiative public use data set and does not necessarily reflect the opinions or views of the Osteoarthritis Initiative investigators, the NIH, or the private funding partners.
Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis†
Article first published online: 28 DEC 2011
Copyright © 2012 by the American College of Rheumatology
Arthritis Care & Research
Volume 64, Issue 1, pages 22–29, January 2012
How to Cite
Beattie, K. A., MacIntyre, N. J., Ramadan, K., Inglis, D. and Maly, M. R. (2012), Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis. Arthritis Care Res, 64: 22–29. doi: 10.1002/acr.20628
- Issue published online: 28 DEC 2011
- Article first published online: 28 DEC 2011
- Accepted manuscript online: 8 SEP 2011 03:38PM EST
- Manuscript Accepted: 30 AUG 2011
- Manuscript Received: 1 APR 2011
- NIH, a branch of the Department of Health and Human Services. Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Osteoarthritis Initiative Study Investigators
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- Foundation for the NIH
- McMaster University Department of Medicine Internal Career Research Award
- Network ScholarAward through the Canadian Arthritis Network
- Natural Sciences and Engineering Research Council of Canada Discovery Grant. Grant Number: 311896
To quantify rates of change in quadriceps muscle (QM) and intermuscular fat (IMF) volumes over 2 years in women in the Osteoarthritis Initiative (OAI) study and examine group differences between those with radiographic osteoarthritis (ROA) and those without ROA.
The OAI database was queried for women ≥50 years of age in the incident and progression cohorts with and without ROA at baseline. Midthigh magnetic resonance imaging scans (15 contiguous slices, 5 mm slice thickness) of eligible women were randomly selected and anonymized. Image pairs were registered. QM and IMF were segmented in the 12 most proximal matching slices with the segmenter blinded to image time point. Age-adjusted differences in QM and IMF volume changes between groups were tested using analysis of covariance.
Forty-one women without ROA (mean ± SD age 60.7 ± 7.6 years) and 45 women with ROA (mean ± SD age 64.5 ± 6.7 years) were included. Mean ± SD QM and IMF volume changes in the non-ROA group were −4.1 ± 11.1 cm3 and 3.4 ± 7.1 cm3, respectively, and −5.4 ± 13.5 cm3 and 3.1 ± 7.4 cm3 in the ROA group, respectively. Age-adjusted between-group differences in QM and IMF changes were not significant (P > 0.05).
Two-year changes in QM and IMF volumes appear consistent with aging and do not seem to be related to OA status. Direct comparison with a control cohort without OA risk factors could confirm this. Since group assignment was based on baseline data, there may have been women in the non-ROA group who developed ROA over followup, resulting in some overlap between groups.