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Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis†

  1. Karen A. Beattie1,*,
  2. Norma J. MacIntyre2,
  3. Khaled Ramadan1,
  4. Dean Inglis1,
  5. Monica R. Maly2

Article first published online: 28 DEC 2011

DOI: 10.1002/acr.20628

Issue

Arthritis Care & Research

Arthritis Care & Research

Volume 64, Issue 1, pages 22–29, January 2012

Additional Information

How to Cite

Beattie, K. A., MacIntyre, N. J., Ramadan, K., Inglis, D. and Maly, M. R. (2012), Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis. Arthritis Care Res, 64: 22–29. doi: 10.1002/acr.20628

Author Information

  1. 1

    McMaster University, Hamilton, Ontario, Canada

  2. 2

    Institute for Applied Health Sciences, Hamilton, Ontario, Canada

*Department of Medicine, McMaster University, c/o 501-25 Charlton Avenue East, Hamilton, Ontario L8N 1Y2, Canada

  1. †

    This article was prepared using an Osteoarthritis Initiative public use data set and does not necessarily reflect the opinions or views of the Osteoarthritis Initiative investigators, the NIH, or the private funding partners.

Publication History

  1. Issue published online: 28 DEC 2011
  2. Article first published online: 28 DEC 2011
  3. Accepted manuscript online: 8 SEP 2011 03:38PM EST
  4. Manuscript Accepted: 30 AUG 2011
  5. Manuscript Received: 1 APR 2011

Funded by

  • NIH, a branch of the Department of Health and Human Services. Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
  • Osteoarthritis Initiative Study Investigators
  • Merck Research Laboratories
  • Novartis Pharmaceuticals Corporation
  • GlaxoSmithKline
  • Pfizer
  • Foundation for the NIH
  • McMaster University Department of Medicine Internal Career Research Award
  • Network ScholarAward through the Canadian Arthritis Network
  • Natural Sciences and Engineering Research Council of Canada Discovery Grant. Grant Number: 311896

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REFERENCES

  • 1
    Creamer P, Hochberg MC. Osteoarthritis. Lancet 1997; 350: 503–8.
  • 2
    Goldring MB, Goldring SR. Osteoarthritis. J Cell Physiol 2007; 213: 626–34.
    Direct Link:
  • 3
    Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW. Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann Intern Med 2003; 138: 613–9.
  • 4
    Gabay O, Hall DJ, Berenbaum F, Henrotin Y, Sanchez C. Osteoarthritis and obesity: experimental models. Joint Bone Spine 2008; 75: 675–9.
  • 5
    Pottie P, Presle N, Terlain B, Netter P, Mainard D, Berenbaum F. Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis 2006; 65: 1403–5.
  • 6
    Anderson JJ, Felson DT. Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I): evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol 1988; 128: 179–89.
  • 7
    Griffin TM, Guilak F. The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev 2005; 33: 195–200.
  • 8
    Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum 2003; 48: 3118–29.
    Direct Link:
  • 9
    Guilak F, Fermor B, Keefe FJ, Kraus VB, Olson SA, Pisetsky DS, et al. The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res 2004; 423: 17–26.
  • 10
    Cicuttini FM, Baker JR, Spector TD. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol 1996; 23: 1221–6.
  • 11
    Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 1999; 10: 161–6.
  • 12
    Gegout PP, Francin PJ, Mainard D, Presle N. Adipokines in osteoarthritis: friends or foes of cartilage homeostasis? Joint Bone Spine 2008; 75: 669–71.
  • 13
    Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548–56.
  • 14
    Ku JH, Lee CK, Joo BS, An BM, Choi SH, Wang TH, et al. Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin Rheumatol 2009; 28: 1431–5.
  • 15
    Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, et al. Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage 2007; 15: 872–83.
  • 16
    Van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-β injections. Osteoarthritis Cartilage 2000; 8: 25–33.
  • 17
    Visser M, Kritchevsky SB, Goodpaster BH, Newman AB, Nevitt M, Stamm E, et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc 2002; 50: 897–904.
    Direct Link:
  • 18
    Hurley MV. Quadriceps weakness in osteoarthritis. Curr Opin Rheumatol 1998; 10: 246–50.
  • 19
    Hurley MV. The role of muscle weakness in the pathogenesis of osteoarthritis. Rheum Dis Clin North Am 1999; 25: 283–98, vi.
  • 20
    Lewek MD, Rudolph KS, Snyder-Mackler L. Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis. J Orthop Res 2004; 22: 110–5.
    Direct Link:
  • 21
    O'Reilly SC, Jones A, Muir KR, Doherty M. Quadriceps weakness in knee osteoarthritis: the effect on pain and disability. Ann Rheum Dis 1998; 57: 588–94.
  • 22
    Slemenda C, Brandt KD, Heilman DK, Mazzuca S, Braunstein EM, Katz BP, et al. Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med 1997; 127: 97–104.
  • 23
    Bennell KL, Hunt MA, Wrigley TV, Lim BW, Hinman RS. Role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am 2008; 34: 731–54.
  • 24
    Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol 2000; 88: 1321–6.
  • 25
    Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 2005; 60: 324–33.
  • 26
    Marcus RL, Addison O, Kidde JP, Dibble LE, Lastayo PC. Skeletal muscle fat infiltration: impact of age, inactivity, and exercise. J Nutr Health Aging 2010; 14: 362–6.
  • 27
    Ikeda S, Tsumura H, Torisu T. Age-related quadriceps-dominant muscle atrophy and incident radiographic knee osteoarthritis. J Orthop Sci 2005; 10: 121–6.
  • 28
    Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, et al. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum 1998; 41: 1951–9.
    Direct Link:
  • 29
    Nevitt M, Felson D, Lester G. The Osteoarthritis Initiative. San Francisco: University of California, San Francisco; 2006.
  • 30
    Nevitt M, Felson D, Lester G. The Osteoarthritis Initiative Protocol for the Cohort Study. Appendix F: Knee MRI Sequence Parameters. The Osteoarthritis Initiative; 2006.
  • 31
    Patel VV, Hall K, Ries M, Lindsey C, Ozhinsky E, Lu Y, et al. Magnetic resonance imaging of patellofemoral kinematics with weight-bearing. J Bone Joint Surg Am 2003; 85: 2419–24.
  • 32
    Cotofana S, Hudelmaier M, Wirth W, Himmer M, Ring-Dimitriou S, Sanger AM, et al. Correlation between single-slice muscle anatomical cross-sectional area and muscle volume in thigh extensors, flexors and adductors of perimenopausal women. Eur J Appl Physiol 2010; 110: 91–7.
  • 33
    Stratford P. Getting more from the literature: estimating the standard error of measurement for reliability studies. Physiother Can 2003; 56: 27–30.
  • 34
    Song MY, Ruts E, Kim J, Janumala I, Heymsfield S, Gallagher D. Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women. Am J Clin Nutr 2004; 79: 874–80.
  • 35
    Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009; 90: 1579–85.
  • 36
    Schaap LA, Pluijm SM, Deeg DJ, Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 2006; 119: 526 e9–17.
  • 37
    Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci 2008; 63: 829–34.
  • 38
    Segal NA, Glass NA, Torner J, Yang M, Felson DT, Sharma L, et al. Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort. Osteoarthritis Cartilage 2010; 18: 769–75.
  • 39
    Segal NA, Torner JC, Felson DT, Niu J, Sharma L, Lewis CE, et al. Knee extensor strength does not protect against incident knee symptoms at 30 months in the multicenter knee osteoarthritis (MOST) cohort. PM R 2009; 1: 459–65.
  • 40
    Segal NA, Torner JC, Felson D, Niu J, Sharma L, Lewis CE, et al. Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort. Arthritis Rheum 2009; 61: 1210–7.
    Direct Link:
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