Drs. Mina and von Scheven contributed equally to this work.
Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus
Version of Record online: 28 FEB 2012
Copyright © 2012 by the American College of Rheumatology
Arthritis Care & Research
Volume 64, Issue 3, pages 375–383, March 2012
How to Cite
Mina, R., von Scheven, E., Ardoin, S. P., Eberhard, B. A., Punaro, M., Ilowite, N., Hsu, J., Klein-gitelman, M., Moorthy, L. N., Muscal, E., Radhakrishna, S. M., Wagner-weiner, L., Adams, M., Blier, P., Buckley, L., Chalom, E., Chédeville, G., Eichenfield, A., Fish, N., Henrickson, M., Hersh, A. O., Hollister, R., Jones, O., Jung, L., Levy, D., Lopez-Benitez, J., McCurdy, D., Miettunen, P. M., Quintero-Del Rio, A. I., Rothman, D., Rullo, O., Ruth, N., Schanberg, L. E., Silverman, E., Singer, N. G., Soep, J., Syed, R., Vogler, L. B., Yalcindag, A., Yildirim-toruner, C., Wallace, C. A., Brunner, H. I. and Carra SLE Subcommittee (2012), Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Arthritis Care Res, 64: 375–383. doi: 10.1002/acr.21558
- Issue online: 28 FEB 2012
- Version of Record online: 28 FEB 2012
- Accepted manuscript online: 12 DEC 2011 02:11PM EST
- Manuscript Accepted: 29 NOV 2011
- Manuscript Received: 2 SEP 2011
- NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Numbers: C1AR058605-01, R13-AR053058-04, K23AR053202, NO1-AR-2-2265, RC2-AR-058934, 1U01AR059509, U01AR055054, P60 AR47784
- Childhood Arthritis and Rheumatology Research Alliance
- Arthritis Foundation
- Wasie Foundation
- Friends of the Childhood Arthritis and Rheumatology Research Alliance
- National Institute of Arthritis and Musculoskeletal and Skin Diseases T32 training grant
To formulate consensus treatment plans (CTPs) for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in juvenile systemic lupus erythematosus (SLE).
A structured consensus formation process was employed by the members of the Childhood Arthritis and Rheumatology Research Alliance after considering the existing medical evidence and current treatment approaches.
After an initial Delphi survey (response rate = 70%), a 2-day consensus conference, and 2 followup Delphi surveys (response rates = 63–79%), consensus was achieved for a limited set of CTPs addressing the induction therapy of proliferative LN. These CTPs were developed for prototypical patients defined by eligibility characteristics, and included immunosuppressive therapy with either mycophenolic acid orally twice per day, or intravenous cyclophosphamide once per month at standardized dosages for 6 months. Additionally, the CTPs describe 3 options for standardized use of glucocorticoids, including a primarily oral, a mixed oral/intravenous, and a primarily intravenous regimen. There was consensus on measures of effectiveness and safety of the CTPs. The CTPs were well accepted by the pediatric rheumatology providers treating children with LN, and up to 300 children per year in North America are expected to be candidates for the treatment with the CTPs.
CTPs for induction therapy of proliferative LN in juvenile SLE based on the available scientific evidence and pediatric rheumatology group experience have been developed. Consistent use of the CTPs may improve the prognosis of proliferative LN, and support the conduct of comparative effectiveness studies aimed at optimizing therapeutic strategies for proliferative LN in juvenile SLE.