Longitudinal study of the bidirectional association between pain and depressive symptoms in patients with psoriatic arthritis
Version of Record online: 23 APR 2012
Copyright © 2012 by the American College of Rheumatology
Arthritis Care & Research
Volume 64, Issue 5, pages 758–765, May 2012
How to Cite
Husted, J. A., Tom, B. D., Farewell, V. T. and Gladman, D. D. (2012), Longitudinal study of the bidirectional association between pain and depressive symptoms in patients with psoriatic arthritis. Arthritis Care Res, 64: 758–765. doi: 10.1002/acr.21602
- Issue online: 2 APR 2012
- Version of Record online: 23 APR 2012
- Accepted manuscript online: 9 JAN 2012 10:59AM EST
- Manuscript Accepted: 4 JAN 2012
- Manuscript Received: 5 MAY 2011
- MRC (unit program). Grant Number: U105261167
- Spondyloarthritis Research Consortium of Canada National Research Initiative from the Arthritis Society
- Krembil Foundation
To test the bidirectional hypothesis that depressive symptoms influence changes in pain over time, and pain influences changes in depressive symptoms.
A total of 394 patients attending the University of Toronto Psoriatic Arthritis clinic were followed over a mean period of 7.5 years with annual assessments, including number of swollen joints (SJC), Health Assessment Questionnaire (HAQ), and the Medical Outcomes Survey Short Form 36 (SF-36). Linear mixed-effects models were used to examine the cross- and lagged associations between the changes in HAQ pain and in the SF-36 mental component summary (MCS) score, adjusting for SJC and other covariates.
The strongest predictors of changes in pain, SJC, and depressive symptoms between visits were scores of the corresponding variables at the previous visit, with standardized regression coefficients exceeding 0.75 in absolute value. There was, however, evidence of a small, but consequential, bidirectional relationship (i.e., standardized regression coefficients <0.3) between depressive symptoms and pain. Both previous MCS scores and change in MCS scores were associated with change in pain between visits; conversely, previous pain scores and change in pain scores were associated with change in depressive symptoms between visits.
Even though cross-variable associations between pain and depressive symptoms exist, changes in pain and depressive symptoms appear to be strongly driven by their measurements at the previous visit. To optimize patient outcomes, a clinical approach that assesses and treats clinically significant depressive symptoms, as well as pain, is required.