Drs. DeWitt and Kimura contributed equally to this work.
Version of Record online: 26 JUN 2012
Copyright © 2012 by the American College of Rheumatology
Arthritis Care & Research
Volume 64, Issue 7, pages 1001–1010, July 2012
How to Cite
Dewitt, E. M., Kimura, Y., Beukelman, T., Nigrovic, P. A., Onel, K., Prahalad, S., Schneider, R., Stoll, M. L., Angeles-Han, S., Milojevic, D., Schikler, K. N., Vehe, R. K., Weiss, J. E., Weiss, P., Ilowite, N. T., Wallace, C. A. and on behalf of the Juvenile Idiopathic Arthritis Disease-specific Research Committee of the Childhood Arthritis Rheumatology and Research Alliance (2012), Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis. Arthritis Care Res, 64: 1001–1010. doi: 10.1002/acr.21625
Members of the CARRA Systemic JIA Core Working Group: Esi Morgan DeWitt, Yukiko Kimura, Timothy Beukelman, Peter A. Nigrovic, Karen Onel, Sampath Prahalad, Rayfel Schneider, Matthew L. Stoll, and Joyce Warshawsky.
Contributing CARRA Members: T. Brent Graham, Judyann Olson, Judy Smith, James Birmingham, Karen Watanabe Duffy, Edward Fels, Sheila Angeles-Han, Raphael Hirsch, Maria Ibarra, Lisa Imundo, Ginger Janow, Michael Miller, Diana Milojevic, Kabita Nanda, Marc Natter, Nancy Olson, Murray Passo, Michael Rapoff, Sarah Ringold, Tova Ronis, Margalit Rosenkranz, Kenneth N. Schikler, Susan Shenoi, David Sherry, Judith Smith, Steven Spalding, Lynn Spiegel, Tracy Ting, Theresa Wampler-Muskardin, Richard K. Vehe, and Lawrence Zemel.
Additional Consensus Meeting Attendees: Patient Representatives Vincent Del Gaizo and Anne Murphy, and CARRA Members Ciaran Duffy, Norman T. Ilowite, Daniel Lovell, Elizabeth Mellins, Michael Rapoff, and Susan Thompson.
- Issue online: 26 JUN 2012
- Version of Record online: 26 JUN 2012
- Accepted manuscript online: 30 JAN 2012 12:00PM EST
- Manuscript Accepted: 23 JAN 2012
- Manuscript Received: 23 SEP 2011
- NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Number: 1RC1-AR-058605-01
- Childhood Arthritis and Rheumatology Research Alliance (CARRA)
- Arthritis Foundation
- Wasie Foundation
- Friends of CARRA
There is wide variation in therapeutic approaches to systemic juvenile idiopathic arthritis (JIA) among North American rheumatologists. Understanding the comparative effectiveness of the diverse therapeutic options available for treatment of systemic JIA can result in better health outcomes. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans and standardized assessment schedules for use in clinical practice to facilitate such studies.
Case-based surveys were administered to CARRA members to identify prevailing treatments for new-onset systemic JIA. A 2-day consensus conference in April 2010 employed modified nominal group technique to formulate preliminary treatment plans and determine important data elements for collection. Followup surveys were employed to refine the plans and assess clinical acceptability.
The initial case-based survey identified significant variability among current treatment approaches for new-onset systemic JIA, underscoring the utility of standardized plans to evaluate comparative effectiveness. We developed 4 consensus treatment plans for the first 9 months of therapy, as well as case definitions and clinical and laboratory monitoring schedules. The 4 treatment regimens included glucocorticoids only, or therapy with methotrexate, anakinra, or tocilizumab, with or without glucocorticoids. This approach was approved by >78% of the CARRA membership.
Four standardized treatment plans were developed for new-onset systemic JIA. Coupled with data collection at defined intervals, use of these treatment plans will create the opportunity to evaluate comparative effectiveness in an observational setting to optimize initial management of systemic JIA.