Drs. Purser and Golightly contributed equally to this work.
Association of slower walking speed with incident knee osteoarthritis–related outcomes†
Article first published online: 26 JUN 2012
Copyright © 2012 by the American College of Rheumatology
Arthritis Care & Research
Volume 64, Issue 7, pages 1028–1035, July 2012
How to Cite
Purser, J. L., Golightly, Y. M., Feng, Q., Helmick, C. G., Renner, J. B. and Jordan, J. M. (2012), Association of slower walking speed with incident knee osteoarthritis–related outcomes. Arthritis Care Res, 64: 1028–1035. doi: 10.1002/acr.21655
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the funding institutes.
- Issue published online: 26 JUN 2012
- Article first published online: 26 JUN 2012
- Accepted manuscript online: 5 MAR 2012 03:47PM EST
- Manuscript Accepted: 27 FEB 2012
- Manuscript Received: 22 AUG 2011
- CDC/Association of Schools of Public Health. Grant Numbers: S043, S1733, S3486
- Multipurpose Arthritis and Musculoskeletal Diseases Center. Grant Number: 5-P60-AR-30701
- Multidisciplinary Clinical Research Center. Grant Number: P60-AR49465
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIH/National Center for Medical Rehabilitation Research. Grant Number: 5K01HD04953
- Claude D. Pepper Older American's Independence Center. Grant Number: NIAP30AG028716
- Arthritis and Immunology T-32 training grant. Grant Number: AR-07416
To determine whether slower walking speed was associated with an increased risk of incident hip and knee osteoarthritis (OA)–related outcomes.
After providing informed consent, community-dwelling participants in the Johnston County Osteoarthritis Project completed 2 home-based interviews and an additional clinic visit for radiographic and physical evaluation. One thousand eight hundred fifty-eight noninstitutionalized residents ages ≥45 years living for at least 1 year in 1 of 6 townships in Johnston County, North Carolina, completed the study's questionnaires and clinical examinations at baseline and at followup testing. Walking time was assessed using a manual stopwatch in 2 trials over an 8-foot distance, and walking speed was calculated as the average of both trials. For the hip and knee, we examined 3 outcomes per joint site: radiographic OA (weight-bearing anteroposterior knee radiographs, supine anteroposterior pelvic radiographs of the hip), chronic joint symptoms, and symptomatic OA. Covariates included age, sex, race, education, marital status, body mass index, number of self-reported chronic conditions diagnosed by a health care provider, number of prescriptions, depressive symptoms, self-rated health, number of lower body functional limitations, smoking, and physical activity.
Faster walking speed was consistently associated with a lower incidence of radiographic (adjusted odds ratio [OR] 0.88, 95% confidence interval [95% CI] 0.79–0.97) and symptomatic knee OA (adjusted OR 0.84, 95% CI 0.75–0.95); slower walking speed was associated with a greater incidence of these outcomes across a broad range of different clinical and radiographic OA outcomes.
Slower walking speed may be a marker for incident knee OA, but other studies must confirm this finding.