Dr. Riddle has received consultancy fees, speaking fees, and/or honoraria (less than $10,000) from the Physical Therapy Editorial Board.
Special Theme Articles: Obesity and the Rheumatic Diseases
Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: A cohort study†
Version of Record online: 27 DEC 2012
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 1, pages 15–22, January 2013
How to Cite
Riddle, D. L. and Stratford, P. W. (2013), Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: A cohort study. Arthritis Care Res, 65: 15–22. doi: 10.1002/acr.21692
This article was prepared using Multicenter Osteoarthritis study data and does not necessarily reflect the opinions or views of the Multicenter Osteoarthritis study investigators. This article was prepared using an Osteoarthritis Initiative public use data set and does not necessarily reflect the opinions or views of the Osteoarthritis Initiative investigators, the NIH, or the private funding partners.
- Issue online: 27 DEC 2012
- Version of Record online: 27 DEC 2012
- Accepted manuscript online: 13 APR 2012 12:07PM EST
- Manuscript Accepted: 26 MAR 2012
- Manuscript Received: 18 OCT 2011
- NIH, a branch of the Department of Health and Human Services. Grant Numbers: AG18820, AG18832, AG18947, AG19069, N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- MOST study investigators
- OAI study investigators
- Foundation for the NIH
To determine if a dose-response relationship exists between percentage changes in body weight in persons with symptomatic knee osteoarthritis (OA) and self-reported pain and function.
Data from persons in the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis (MOST) study data sets (n = 1,410) with symptomatic function-limiting knee OA were studied. For the OAI, we used baseline and 3-year followup data, while for the MOST study, baseline and 30-month data were used. Key outcome variables were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function and pain change scores. In addition to covariates, the predictor variable of interest was the extent of weight change over the study period divided into 5 categories representing different percentages of body weight change.
A significant dose-response relationship (P < 0.003) was found between the extent of percentage change in body weight and the extent of change in WOMAC physical function and WOMAC pain scores. For example, persons who gained ≥10% of body weight had WOMAC physical function score changes of −5.4 (95% confidence interval −8.7, −2.00) points, indicating worsening physical function relative to the reference group of persons with weight changes between <5% weight gain and <5% weight reduction.
Our data suggest a dose-response relationship exists between changes in body weight and corresponding changes in pain and function. The threshold for this response gradient appears to be body weight shifts of ≥10%. Weight changes of ≥10% have the potential to lead to important changes in pain and function for patient groups as well as individual patients.