Dr. Wirth is co-owner of Chondrometrics, has received consultant fees, speaking fees, and/or honoraria (less than $10,000) from Merck Serono, and owns stock or stock options in Chondrometrics.
Cartilage thickening in early radiographic knee osteoarthritis: A within-person, between-knee comparison
Article first published online: 27 OCT 2012
Copyright © 2012 by the American College of Rheumatology
Arthritis Care & Research
Volume 64, Issue 11, pages 1681–1690, November 2012
How to Cite
Cotofana, S., Buck, R., Wirth, W., Roemer, F., Duryea, J., Nevitt, M., Eckstein, F. and Osteoarthritis Initiative Investigators Group (2012), Cartilage thickening in early radiographic knee osteoarthritis: A within-person, between-knee comparison. Arthritis Care Res, 64: 1681–1690. doi: 10.1002/acr.21719
- Issue published online: 27 OCT 2012
- Article first published online: 27 OCT 2012
- Accepted manuscript online: 3 MAY 2012 10:25AM EST
- Manuscript Accepted: 24 APR 2012
- Manuscript Received: 28 OCT 2011
- Merck Serono S.A.
- Osteoarthritis Initiative (NIH). Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Paracelsus Medical University Forschungsförderungsfond
To determine whether the presence of definite osteophytes (in the absence of joint space narrowing [JSN]) on radiographs is associated with (subregional) increases in cartilage thickness in a within-person, between-knee cross-sectional comparison of participants in the Osteoarthritis Initiative. Based on previous results, the external weight-bearing medial femoral condyle (ecMF) and external weight-bearing lateral femoral condyle (ecLF) subregions were selected as primary end points.
Both knees of 61 Osteoarthritis Initiative participants (n = 4,796) displayed definite tibial or femoral marginal osteophytes and no JSN in 1 knee, and no signs of radiographic osteoarthritis (OA) in the contralateral knee; this was confirmed by an expert central reader. In these participants, cartilage thickness was measured in 16 femorotibial subregions of each knee, based on sagittal double-echo steady-state with water excitation magnetic resonance images. Location-specific joint space width from fixed-flexion radiographs was determined using dedicated software. Location-specific associations of osteophytes with cartilage thickness were evaluated using paired t-tests and mixed-effects models.
Of the 61 participants, 48% had only medial osteophytes, 36% only lateral osteophytes, and 16% bicompartmental osteophytes. The knees with osteophytes had significantly thicker cartilage than contralateral knees without osteophytes in the ecMF (mean ± SD +71 ± 223 μmoles, equivalent to an increase of +5.5%; P = 0.015) and ecLF (mean ± SD +64 ± 195 μmoles, +4.1%; P = 0.013). No significant differences between knees were noted in other subregions or in joint space width. Cartilage thickness in the ecMF and ecLF was significantly associated with tibial osteophytes in the same (medial or lateral) compartment (P = 0.003).
The knees with early radiographic OA display thicker cartilage than (contralateral) knees without radiographic findings of OA, specifically in the external femoral subregions of compartments with marginal osteophytes.