• 1
    Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007; 369: 76778.
  • 2
    Martini A, Lovell DJ. Juvenile idiopathic arthritis: state of the art and future perspectives. Ann Rheum Dis 2010; 69: 12603.
  • 3
    Breedveld F. The value of early intervention in RA: a window of opportunity. Clin Rheumatol 2011; 30 Suppl 1: S339.
  • 4
    Ostergaard M, Peterfy C, Conaghan P, McQueen F, Bird P, Ejbjerg B, et al. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol 2003; 30: 13856.
  • 5
    Malattia C, Damasio MB, Pistorio A, Ioseliani M, Vilca I, Valle M, et al. Development and preliminary validation of a paediatric-targeted MRI scoring system for the assessment of disease activity and damage in juvenile idiopathic arthritis. Ann Rheum Dis 2010; 70: 4406.
  • 6
    Hodgson RJ, O'Connor P, Moots R. MRI of rheumatoid arthritis–image quantitation for the assessment of disease activity, progression and response to therapy. Rheumatology (Oxford) 2008; 47: 1321.
  • 7
    Ostergaard M. Different approaches to synovial membrane volume determination by magnetic resonance imaging: manual versus automated segmentation. Br J Rheumatol 1997; 36: 116677.
  • 8
    Ostergaard M, Hansen M, Stoltenberg M, Gideon P, Klarlund M, Jensen KE, et al. Magnetic resonance imaging–determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis. Arthritis Rheum 1999; 42: 91829.
  • 9
    Zikou AK, Argyropoulou MI, Voulgari PV, Xydis VG, Nikas SN, Efremidis SC, et al. Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with adalimumab. J Rheumatol 2006; 33: 21923.
  • 10
    Sugimoto H, Takeda A, Kano S. Assessment of disease activity in rheumatoid arthritis using magnetic resonance imaging: quantification of pannus volume in hands. Br J Rheumatol 1998; 37: 85461.
  • 11
    Bird P, Lassere M, Shnier R, Edmonds J. Computerized measurement of magnetic resonance imaging erosion volumes in patients with rheumatoid arthritis: a comparison with existing magnetic resonance imaging scoring systems and standard clinical outcome measures. Arthritis Rheum 2003; 48: 61424.
  • 12
    Graham TB, Laor T, Dardzinski BJ. Quantitative magnetic resonance imaging of the hands and wrists of children with juvenile rheumatoid arthritis. J Rheumatol 2005; 32: 181120.
  • 13
    Gylys-Morin VM, Graham TB, Blebea JS, Dardzinski BJ, Laor T, Johnson ND, et al. Knee in early juvenile rheumatoid arthritis: MR imaging findings. Radiology 2001; 220: 696706.
  • 14
    Savnik A, Bliddal H, Nyengaard J, Thomsen HS. MRI of the arthritic finger joints: synovial membrane volume determination, a manual versus a stereologic method. Eur Radiol 2002; 12: 948.
  • 15
    Tam LS, Griffith J, Yu AB, Li TK, Li EK. Rapid improvement in rheumatoid arthritis patients on combination of methotrexate and infliximab: clinical and magnetic resonance imaging evaluation. Clin Rheumatol 2007; 26: 9416.
  • 16
    Palmer WE, Rosenthal DI, Schoenberg OI, Fischman AJ, Simon LS, Rubin RH, et al. Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-(F-18)-fluoro-2-deoxy-D-glucose. Radiology 1995; 196: 64755.
  • 17
    Fritz J, Galeczko EK, Schwenzer N, Fenchel M, Claussen CD, Carrino JA, et al. Longitudinal changes in rheumatoid arthritis after rituximab administration assessed by quantitative and dynamic contrast-enhanced 3-T MR imaging: preliminary findings. Eur Radiol 2009; 19: 221724.
  • 18
    Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton 2001. J Rheumatol 2004; 31: 3902.
  • 19
    Giannini EH, Brewer EJ Jr. Standard methodology for Segment I, II, and III Pediatric Rheumatology Collaborative Study Group studies. II. Analysis and presentation of data. J Rheumatol 1982; 9: 11422.
  • 20
    Ruperto N, Ravelli A, Pistorio A, Malattia C, Viola S, Cavuto S, et al. The Italian version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Clin Exp Rheumatol 2001; Suppl 23: S915.
  • 21
    Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G, et al, and the Paediatric Rheumatology International Trials Organisation. Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis Rheum 2009; 61: 65866.
  • 22
    Viola S, Felici E, Magni-Manzoni S, Pistorio A, Buoncompagni A, Ruperto N, et al. Development and validation of a clinical index for assessment of long-term damage in juvenile idiopathic arthritis. Arthritis Rheum 2005; 52: 2092102.
  • 23
    Giannini EH, Ruperto N, Ravelli A, Lovell DJ, Felson DT, Martini A. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum 1997; 40: 12029.
  • 24
    Basso C, Santoro M, Verri A, Esposito M. Segmentation of inflamed synovia in multi-modal 3D MRI. Proceedings of IEEE International Symposium on Biomedical Imaging: from Nano to Macro. Piscataway (NJ): IEEE Press; 2009 p. 22932.
  • 25
    Gonzalez R, Woods R. Digital image processing. 3rd ed. Upper Saddle River (NJ): Pearson Education; 2008.
  • 26
    Mattes D, Haynor D, Vesselle H, Lewellen T, Eubank W. PET-CT image registration in the chest using free-form deformations. IEEE Trans Med Imaging 2003; 22: 1208.
  • 27
    Ravelli A, Ioseliani M, Norambuena X, Sato J, Pistorio A, Rossi F, et al. Adapted versions of the Sharp/van der Heijde score are reliable and valid for assessment of radiographic progression in juvenile idiopathic arthritis. Arthritis Rheum 2007; 56: 308795.
  • 28
    Poznanski AK, Hernandez RJ, Guire KE, Bereza UL, Garn SM. Carpal length in children: a useful measurement in the diagnosis of rheumatoid arthritis and some congenital malformation syndromes. Radiology 1978; 129: 6618.
  • 29
    Deyo RA, Diehr P, Patrick DL. Reproducibility and responsiveness of health status measures: statistics and strategies for evaluation. Control Clin Trials 1991; 12: 14258S.
  • 30
    Swinscow TD. Statistics at square one. 9th ed. Campbell MJ, editor. Southampton: BMJ Publishing; 1997. p. 78.
  • 31
    Liang MH, Larson MG, Cullen KE, Schwartz JA. Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research. Arthritis Rheum 1985; 28: 5427.
  • 32
    Obuchowski NA. Receiver operating characteristic curves and their use in radiology. Radiology 2003; 229: 38.
  • 33
    Boyesen P, Haavardsholm EA, van der Heijde D, Ostergaard M, Hammer HB, Sesseng S, et al. Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patients. Ann Rheum Dis 2011; 70: 1769.
  • 34
    Boers M, Brooks P, Strand V, Strand CV, Tugwell P. The OMERACT filter for outcome measures in rheumatology. J Rheumatol 1998; 25: 1989.
  • 35
    Ostergaard M, Stoltenberg M, Lovgreen-Nielsen P, Volck B, Jensen CH, Lorenzen I. Magnetic resonance imaging–determined synovial membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis: comparison with the macroscopic and microscopic appearance of the synovium. Arthritis Rheum 1997; 40: 185667.
  • 36
    Ostergaard M, Gideon P, Henriksen O, Lorenzen I. Synovial volume: a marker of disease severity in rheumatoid arthritis? Quantification by MRI. Scand J Rheumatol 1994; 23: 197202.
  • 37
    Ostergaard M, Hansen M, Stoltenberg M, Lorenzen I. Quantitative assessment of the synovial membrane in the rheumatoid wrist: an easily obtained MRI score reflects the synovial volume. Br J Rheumatol 1996; 35: 96571.
  • 38
    Backhaus M, Kamradt T, Sandrock D, Loreck D, Fritz J, Wolf KJ, et al. Arthritis of the finger joints: a comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging. Arthritis Rheum 1999; 42: 123245.
  • 39
    Neumann G, dePablo P, Finckh A, Chibnik LB, Wolfe F, Duryea J. Patient repositioning reproducibility of joint space width measurements on hand radiographs. Arthritis Care Res (Hoboken) 2011; 63: 2037.
  • 40
    McQueen FM, Stewart N, Crabbe J, Robinson E, Yeoman S, Tan PL, et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset. Ann Rheum Dis 1998; 57: 3506.
  • 41
    Malattia C, Damasio MB, Magnaguagno F, Pistorio A, Valle M, Martinoli C, et al. Magnetic resonance imaging, ultrasonography, and conventional radiography in the assessment of bone erosions in juvenile idiopathic arthritis. Arthritis Rheum 2008; 59: 176472.
  • 42
    Peterfy CG. MRI of the wrist in early rheumatoid arthritis. Ann Rheum Dis 2004; 63: 4737.
  • 43
    McQueen FM, Benton N, Crabbe J, Robinson E, Yeoman S, McLean L, et al. What is the fate of erosions in early rheumatoid arthritis? Tracking individual lesions using x rays and magnetic resonance imaging over the first two years of disease. Ann Rheum Dis 2001; 60: 85968.
  • 44
    Brown AK, Conaghan PG, Karim Z, Quinn MA, Ikeda K, Peterfy CG, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum 2008; 58: 295867.
  • 45
    McQueen FM, Stewart N, Crabbe J, Robinson E, Yeoman S, Tan PL, et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. Ann Rheum Dis 1999; 58: 15663.
  • 46
    Muller LS, Avenarius D, Damasio B, Eldevik OP, Malattia C, Lambot-Juhan K, et al. The paediatric wrist revisited: redefining MR findings in healthy children. Ann Rheum Dis 2011; 70: 60510.
  • 47
    Magni-Manzoni S, Rossi F, Pistorio A, Temporini F, Viola S, Beluffi G, et al. Prognostic factors for radiographic progression, radiographic damage, and disability in juvenile idiopathic arthritis. Arthritis Rheum 2003; 48: 350917.