• 1
    Jinks C, Jordan K, Ong BN, Croft P. A brief screening tool for knee pain in primary care (KNEST). 2. Results from a survey in the general population aged 50 and over. Rheumatology (Oxford) 2004; 43: 5561.
  • 2
    Zhai G, Blizzard L, Srikanth V, Ding C, Cooley H, Cicuttini F, et al. Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study. Arthritis Rheum 2006; 55: 26471.
  • 3
    Jinks C, Jordan K, Croft P. Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community. (KNEST 3). Rheumatology (Oxford) 2007; 46: 87781.
  • 4
    Jinks C, Jordan KP, Blagojevic M, Croft P. Predictors of onset and progression of knee pain in adults living in the community: a prospective study. Rheumatology (Oxford) 2008; 47: 36874.
  • 5
    Miranda H, Viikari-Juntura E, Martikainen R, Riihimki H. A prospective study on knee pain and its risk factors. Osteoarthritis Cartilage 2002; 10: 62330.
  • 6
    Webb R, Brammah T, Lunt M, Urwin M, Allison T, Symmons D. Opportunities for prevention of ‘clinically significant’ knee pain: results from a population-based cross sectional survey. J Public Health (Oxf) 2004; 26: 27784.
  • 7
    Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women: the Framingham Study. Ann Intern Med 1992; 116: 5359.
  • 8
    Christensen R, Astrup A, Bliddal H. Weight loss: the treatment of choice for knee osteoarthritis? A randomized trial. Osteoarthritis Cartilage 2005; 13: 207.
  • 9
    Messier SP, Loeser RF, Miller GD, Morgan TM, Rejeski WJ, Sevick MA, et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum 2004; 50: 150110.
  • 10
    Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III. Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010; 18: 47699.
  • 11
    Richette P, Poitou C, Garnero P, Vicaut E, Bouillot JL, Lacorte JM, et al. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis 2011; 70: 13944.
  • 12
    Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988; 15: 183340.
  • 13
    Hanna FS, Bell RJ, Davis SR, Wluka AE, Teichtahl AJ, O'Sullivan R, et al. Factors affecting patella cartilage and bone in middle-aged women. Arthritis Rheum 2007; 57: 2728.
  • 14
    Guymer E, Baranyay F, Wluka AE, Hanna F, Bell RJ, Davis SR, et al. A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women. Osteoarthritis Cartilage 2007; 15: 143742.
  • 15
    Lo GH, Hunter DJ, LaValley M, Zhang YQ, McLennan C, Niu JB, et al. Higher sensitivity for osteophytes on MRI [abstract]. Arthritis Rheum 2004; 50 Suppl: S143.
  • 16
    Doherty M, Hawkey C, Goulder M, Gibb I, Hill N, Aspley S, et al. A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. Ann Rheum Dis 2011; 70: 153441.
  • 17
    Dore D, Quinn S, Ding C, Winzenberg T, Zhai G, Cicuttini F, et al. Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults. Arthritis Res Ther 2010; 12: R223.
  • 18
    Kim IJ, Kim HA, Seo YI, Jung YO, Song YW, Jeong JY, et al. Prevalence of knee pain and its influence on quality of life and physical function in the Korean elderly population: a community based cross-sectional study. J Korean Med Sci 2011; 26: 11406.
  • 19
    Wood LR, Peat GM, Mullis R, Thomas E, Foster NE. Impairment-targeted exercises for older adults with knee pain: protocol for a proof-of-principle study. BMC Musculoskelet Disord 2011; 12: 2.
  • 20
    Center for Drug Evaluation and Research, Food and Drug Administration, US Department of Health and Human Services. Guidance for industry: developing products for weight management. Rockville (MD): DHHS; 2007. URL:
  • 21
    Adamson J, Ebrahim S, Dieppe P, Hunt K. Prevalence and risk factors for joint pain among men and women in the West of Scotland Twenty-07 study. Ann Rheum Dis 2006; 65: 5204.
  • 22
    Jinks C, Jordan K, Croft P. Disabling knee pain—another consequence of obesity: results from a prospective cohort study. BMC Public Health 2006; 6: 258.
  • 23
    Soni A, Kiran A, Hart DJ, Leyland KM, Goulston L, Cooper C, et al. Prevalence of reported knee pain over twelve years in a community-based cohort. Arthritis Rheum 2012; 64: 114552.
  • 24
    Hart DJ, Spector TD. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 1993; 20: 3315.
  • 25
    Manninen P, Riihimaki H, Heliovaara M, Suomalainen O. Weight changes and the risk of knee osteoarthritis requiring arthroplasty. Ann Rheum Dis 2004; 63: 14347.
  • 26
    Hills AP, Hennig EM, Byrne NM, Steele JR. The biomechanics of adiposity: structural and functional limitations of obesity and implications for movement [review]. Obes Rev 2002; 3: 3543.
  • 27
    Schipplein OD, Andriacchi TP. Interaction between active and passive knee stabilizers during level walking. J Orthop Res 1991; 9: 1139.
  • 28
    Schwarzenberg SJ, Sinaiko AR. Obesity and inflammation in children. Paediatr Respir Rev 2006; 7: 23946.
  • 29
    Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010; 314: 116.
  • 30
    Dina OA, Green PG, Levine JD. Role of interleukin-6 in chronic muscle hyperalgesic priming. Neuroscience 2008; 152: 5215.
  • 31
    Wang H, Schiltenwolf M, Buchner M. The role of TNF-α in patients with chronic low back pain: a prospective comparative longitudinal study. Clin J Pain 2008; 24: 2738.
  • 32
    Miller GD, Nicklas BJ, Davis C, Loeser RF, Lenchik L, Messier SP. Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity 2006; 14: 121930.
  • 33
    Hill JO. Can a small-changes approach help address the obesity epidemic? A report of the Joint Task Force of the American Society for Nutrition, Institute of Food Technologists, and International Food Information Council. Am J Clin Nutr 2009; 89: 47784.
  • 34
    Barte JC, ter Bogt NC, Bogers RP, Teixeira PJ, Blissmer B, Mori TA, et al. Maintenance of weight loss after lifestyle interventions for overweight and obesity, a systematic review. Obes Rev 2010; 11: 899906.
  • 35
    Weiss EC, Galuska DA, Kettel Khan L, Gillespie C, Serdula MK. Weight regain in US adults who experienced substantial weight loss, 1999-2002. Am J Prev Med 2007; 33: 3440.
  • 36
    Ball K, Brown W, Crawford D. Who does not gain weight? Prevalence and predictors of weight maintenance in young women. Int J Obes Relat Metab Disord 2002; 26: 15708.
  • 37
    St Jeor ST, Brunner RL, Harrington ME, Scott BJ, Cutter GR, Brownell KD, et al. Who are the weight maintainers? Obes Res 1995; 3 Suppl: 249s59s.
  • 38
    Sherwood NE, Jeffery RW, Pronk NP, Boucher JL, Hanson A, Boyle R, et al. Mail and phone interventions for weight loss in a managed-care setting: weigh-to-be 2-year outcomes. Int J Obes (Lond) 2006; 30: 156573.
  • 39
    Walls HL, Magliano DJ, Stevenson CE, Backholer K, Mannan HR, Shaw JE, et al. Projected progression of the prevalence of obesity in Australia. Obesity (Silver Spring) 2012; 20: 8728.