Dr. Eaton has received honoraria (less than $10,000) from the Medical University of South Carolina.
Special Theme Articles: Obesity and the Rheumatic Diseases
Version of Record online: 27 DEC 2012
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 1, pages 53–61, January 2013
How to Cite
Lee, J., Song, J., Hootman, J. M., Semanik, P. A., Chang, R. W., Sharma, L., van Horn, L., Bathon, J. M., Eaton, C. B., Hochberg, M. C., Jackson, R., Kwoh, C. K., Mysiw, W. J., Nevitt, M. and Dunlop, D. D. (2013), Obesity and other modifiable factors for physical inactivity measured by accelerometer in adults with knee osteoarthritis. Arthritis Care Res, 65: 53–61. doi: 10.1002/acr.21754
ClinicalTrials.gov identifier: NCT0080171.
The findings and conclusions herein are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the Osteoarthritis Initiative.
- Issue online: 27 DEC 2012
- Version of Record online: 27 DEC 2012
- Accepted manuscript online: 5 JUN 2012 10:35AM EST
- Manuscript Accepted: 25 MAY 2012
- Manuscript Received: 1 FEB 2012
- National Institute for Arthritis and Musculoskeletal Diseases. Grant Numbers: P60-AR48098, R01-AR055287, R01-AR054155, R21-AR059412
- Falk Medical Research Trust
- The Osteoarthritis Initiative (OAI). Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Merck Research Laboratories
- Novartis Pharmaceuticals
To investigate the public health impact of obesity and other modifiable risk factors related to physical inactivity in adults with knee osteoarthritis (OA).
The frequency of inactivity as defined by the US Department of Health and Human Services was assessed from objective accelerometer monitoring of 1,089 participants (ages 49–84 years) with radiographic knee OA during the Osteoarthritis Initiative 48-month visit (2008–2010). The relationship between modifiable factors (weight status, dietary fat, fiber, smoking, depressive symptoms, knee function, knee pain, and knee confidence) with inactivity was assessed using odds ratios (ORs) and attributable fractions (AFs), controlling for descriptive factors (age, sex, race, education, lives alone, employment, frequent knee symptoms, and comorbidity).
Almost half (48.9%) of participants with knee OA were inactive. Being overweight (OR 1.8, 95% confidence interval [95% CI] 1.2–2.5) or obese (OR 3.9, 95% CI 2.6–5.7), having inadequate dietary fiber intake (OR 1.6, 95% CI 1.2–2.2), severe knee dysfunction (OR 1.9, 95% CI 1.3–2.8), and severe pain (OR 1.7, 95% CI 1.1–2.5) were significantly related to inactivity, controlling for descriptive factors. Modifiable factors with significant average AFs were being overweight or obese (AF 23.8%, 95% CI 10.5–38.6%) and inadequate dietary fiber (AF 12.1%, 95% CI 0.1–24.5%), controlling for all factors.
Being obese or overweight, the quality of the diet, severe pain, and severe dysfunction are significantly associated with physical inactivity in adults with knee OA. All components should be considered in designing physical activity interventions that target arthritis populations with low activity levels.