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Validation of the Pediatric Automated Neuropsychological Assessment Metrics in childhood-onset systemic lupus erythematosus†
Article first published online: 26 FEB 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 3, pages 372–381, March 2013
How to Cite
Brunner, H. I., Klein-Gitelman, M. S., Zelko, F., Thomas, E. C., Hummel, J., Nelson, S. M., Huggins, J., Curran, M. L., Roebuck-Spencer, T., Beebe, D. W. and Ying, J. (2013), Validation of the Pediatric Automated Neuropsychological Assessment Metrics in childhood-onset systemic lupus erythematosus. Arthritis Care Res, 65: 372–381. doi: 10.1002/acr.21835
- Issue published online: 21 FEB 2013
- Article first published online: 26 FEB 2013
- Accepted manuscript online: 29 AUG 2012 03:05PM EST
- Manuscript Accepted: 13 AUG 2012
- Manuscript Received: 17 JUN 2012
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Clinical Research Center. Grant Number: P60-AR047884
- Institutional Clinical and Translational Science Award (NIH/National Center for Research Resources. Grant Numbers: UL1-TR-000077-04, UL1-RR-026314-03
To evaluate the reproducibility and validity of the Pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) when used in childhood-onset systemic lupus erythematosus (cSLE).
Forty children with cSLE and 40 matched controls were followed for up to 18 months. Formal neuropsychological testing at baseline was repeated after 18 months of followup; overall cognitive performance and domain-specific cognition (attention, working memory, processing speed, and visuoconstructional ability) were measured and categorized as normal cognition, mild/moderate, or moderate/severe impairment. The 10 Ped-ANAM subtests were completed every 6 months and twice at baseline. Ped-ANAM performance was based on accuracy (AC), mean time to correct response (MNc), throughput, and coefficient of variation of the time required for a correct response (CVc) as a measure of response consistency.
Particularly, MNc scores demonstrated moderate to substantial reproducibility (intraclass correlation coefficients 0.47–0.80). Means of select Ped-ANAM scores (MNc, AC, CVc) differed significantly between children with different levels of cognitive performance and allowed for the detection of moderate or severe cognitive impairment with 100% sensitivity and 86% specificity. Six Ped-ANAM subtests significantly correlated with the change in overall cognitive function in cSLE (baseline versus 18 months; Spearman's correlation coefficient >0.4, P < 0.05; n = 24).
The Ped-ANAM has moderate to substantial reproducibility, criterion and construct validity, and may be responsive to change in cSLE. Additional research is required to confirm the outstanding accuracy of the Ped-ANAM in identifying cognitive impairment, as well as its usefulness in detecting clinically relevant changes in cognition over time.