This article was prepared using an Osteoarthritis Initiative public use data set and does not necessarily reflect the opinions or views of the Osteoarthritis Initiative investigators, the NIH, or the private funding partners.
Special Theme Articles: Obesity and the Rheumatic Diseases
Relationship of intermuscular fat volume in the thigh with knee extensor strength and physical performance in women at risk of or with knee osteoarthritis†
Article first published online: 27 DEC 2012
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 1, pages 44–52, January 2013
How to Cite
Maly, M. R., Calder, K. M., MacIntyre, N. J. and Beattie, K. A. (2013), Relationship of intermuscular fat volume in the thigh with knee extensor strength and physical performance in women at risk of or with knee osteoarthritis. Arthritis Care Res, 65: 44–52. doi: 10.1002/acr.21868
- Issue published online: 27 DEC 2012
- Article first published online: 27 DEC 2012
- Accepted manuscript online: 8 OCT 2012 12:12PM EST
- Manuscript Accepted: 25 SEP 2012
- Manuscript Received: 30 JAN 2012
- NIH, a branch of the Department of Health and Human Services. Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Osteoarthritis Initiative Study Investigators
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- Foundation for the NIH
- New Investigator Award from the Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada Discovery Grant. Grant Numbers: 353715, 311896
- Canadian Institutes of Health Research Joint Motion Program Postdoctoral Fellowship
- Network Scholar Award through The Arthritis Society/Canadian Arthritis Network
To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without.
Baseline data from 125 women (age ≥50 years) in the Osteoarthritis Initiative study, with or at risk of knee ROA were included. Knee extensor strength was measured using a fixed force transducer, normalized to body mass (N/kg). Physical performance was the time required for 5 repeated chair stands (seconds). The IMF and QM volumes, normalized to height (cm3/meter), were yielded from analyses of T1-weighted axial magnetic resonance images of the midthigh. Mean IMF and QM volumes, extensor strength, and physical performance were compared between women with and without ROA, controlling for age. Hierarchical multiple regressions determined whether IMF and QM volumes were related to strength and performance after controlling for age, ROA status (yes/no), alignment, and pain.
Compared to subjects with ROA, the subjects without ROA were stronger and performed chair stands faster (P < 0.05). After adjusting for age, those subjects without ROA had less mean ± SD IMF (61.1 ± 20.3 cm3/meter) compared to mean ± SD ROA (72.0 ± 25.0 cm3/meter; P < 0.05). In the entire sample, 21.1% of variance in knee extensor strength was explained by alignment, pain, and IMF. A model explaining 13.4% of variance in physical performance included OA status and IMF. QM volume was unrelated to strength and physical performance.
IMF volume explained a small amount of variance in knee extensor strength and physical performance among women with or at risk of knee ROA.