Dr. Losina has received fees from her role as Deputy Editor of The Journal of Bone and Joint Surgery.
Lifetime Risk and Age at Diagnosis of Symptomatic Knee Osteoarthritis in the US
Version of Record online: 23 APR 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 5, pages 703–711, May 2013
How to Cite
Losina, E., Weinstein, A. M., Reichmann, W. M., Burbine, S. A., Solomon, D. H., Daigle, M. E., Rome, B. N., Chen, S. P., Hunter, D. J., Suter, L. G., Jordan, J. M. and Katz, J. N. (2013), Lifetime Risk and Age at Diagnosis of Symptomatic Knee Osteoarthritis in the US. Arthritis Care Res, 65: 703–711. doi: 10.1002/acr.21898
- Issue online: 23 APR 2013
- Version of Record online: 23 APR 2013
- Accepted manuscript online: 30 NOV 2012 03:54PM EST
- Manuscript Accepted: 23 OCT 2012
- Manuscript Received: 17 APR 2012
- NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Numbers: R01-AR053112, K24-AR057827, K23-AR054095, P60-AR47782, T32-AR-055885
- VA Connecticut Healthcare System and the Centers for Medicare and Medicaid Services
- An Agency of the US Department of Health and Human Services. Grant Number: HHSM-500-2008-0025I/HHSM-500-T0001
To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population.
We estimated the incidence of diagnosed symptomatic knee OA in the US by combining data on age-, sex-, and obesity-specific prevalence from the 2007–2008 National Health Interview Survey, with disease duration estimates derived from the Osteoarthritis Policy (OAPol) Model, a validated computer simulation model of knee OA. We used the OAPol Model to estimate the mean and median ages at diagnosis and lifetime risk.
The estimated incidence of diagnosed symptomatic knee OA was highest among adults ages 55–64 years, ranging from 0.37% per year for nonobese men to 1.02% per year for obese women. The estimated median age at knee OA diagnosis was 55 years. The estimated lifetime risk was 13.83%, ranging from 9.60% for nonobese men to 23.87% in obese women. Approximately 9.29% of the US population is diagnosed with symptomatic knee OA by age 60 years.
The diagnosis of symptomatic knee OA occurs relatively early in life, suggesting that prevention programs should be offered relatively early in the life course. Further research is needed to understand the future burden of health care utilization resulting from earlier diagnosis of knee OA.