ClinicalTrials.gov identifier: NCT00512239.
Predictors of Pain for Patients With Early Inflammatory Polyarthritis
Version of Record online: 30 MAY 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 6, pages 992–999, June 2013
How to Cite
Dobkin, P. L., Liu, A., Abrahamowicz, M., Carrier, N., de Brum-Fernandes, A. J., Cossette, P. and Boire, G. (2013), Predictors of Pain for Patients With Early Inflammatory Polyarthritis. Arthritis Care Res, 65: 992–999. doi: 10.1002/acr.21923
- Issue online: 30 MAY 2013
- Version of Record online: 30 MAY 2013
- Accepted manuscript online: 19 DEC 2012 12:00AM EST
- Manuscript Accepted: 27 NOV 2012
- Manuscript Received: 13 JUN 2012
- Canadian Arthritis Network (Graduate Training Award)
- Arthritis Society. Grant Number: RG06/108
- Canadian Institutes of Health Research. Grant Number: MOP-110959
To identify predictors of pain at 1 year in patients with early inflammatory polyarthritis (EIP).
Using a prospective design, patients were examined by a rheumatologist and completed questionnaires at baseline and at 1 year after symptom onset. Separate regression analyses were run for pain intensity, sensory pain, and affective pain. Age and sex were adjusted in cross-sectional and longitudinal analyses; baseline potential predictors consisted of measures for corresponding pain values and disease activity, depression, coping scores, medication use, rheumatoid arthritis criteria being met, and duration of symptoms.
A total of 211 patients were enrolled in the study (mean ± SD age 58.8 ± 14.2 years, 63% women). There were significant improvements at 1 year for disease activity, instrumental coping, emotional coping, depression, and all 3 pain measures. At baseline, disease activity and depression were positively associated with all types of pain; in addition, instrumental coping was positively associated with sensory pain and palliative coping was positively associated with affective pain. At 1 year, pain intensity was predicted by baseline pain intensity, duration of symptoms, use of disease-modifying antirheumatic drugs (DMARDs), and emotional coping. Sensory pain was predicted by baseline sensory pain and DMARD use. Affective pain was predicted by baseline affective pain, DMARD use, and emotional coping.
The majority of treated EIP patients can expect improvements in clinical and psychosocial variables over the first year of their illness. Emotional coping at baseline may contribute to pain in the future, and therefore it may be useful for patients to learn other means of dealing with this chronic disease.