Dr. Cibere has received consultant fees, speaking fees, and/or honoraria (less than $10,000 each) from Pfizer, Eli Lilly, and IBEX, and has received investigator-initiated grant funding from Amgen.
Occurrence of Radiographic Osteoarthritis of the Knee and Hip Among African Americans and Whites: A Population-Based Prospective Cohort Study
Article first published online: 30 MAY 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 6, pages 928–935, June 2013
How to Cite
Kopec, J. A., Sayre, E. C., Schwartz, T. A., Renner, J. B., Helmick, C. G., Badley, E. M., Cibere, J., Callahan, L. F. and Jordan, J. M. (2013), Occurrence of Radiographic Osteoarthritis of the Knee and Hip Among African Americans and Whites: A Population-Based Prospective Cohort Study. Arthritis Care Res, 65: 928–935. doi: 10.1002/acr.21924
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
- Issue published online: 30 MAY 2013
- Article first published online: 30 MAY 2013
- Accepted manuscript online: 19 DEC 2012 12:00AM EST
- Manuscript Accepted: 27 NOV 2012
- Manuscript Received: 3 APR 2012
- CDC/Association of Schools of Public Health. Grant Numbers: S043, S3486
- Multipurpose Arthritis and Musculoskeletal Diseases Center. Grant Number: 5-P60-AR-30701
- Multidisciplinary Clinical Research Center. Grant Number: 5-P60-AR49465 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases
To compare the incidence and progression of radiographic osteoarthritis (OA) in the knee and hip among African Americans and whites.
Using the joint as the unit of analysis, we analyzed data from the Johnston County Osteoarthritis Project, a population-based prospective cohort study in rural North Carolina. Baseline and followup assessments were 3–13 years apart. Assessments included standard knee and hip radiographs read for Kellgren/Lawrence (K/L) radiographic grade. Weighted analyses controlled for age, sex, body mass index, level of education, and baseline K/L grade; bootstrap methods adjusted for lack of independence between left and right joints. Time-to-event analysis was used to analyze the data.
For radiographic knee OA, being African American had no association with incidence (adjusted hazard ratio [HRadj] 0.80, 95% confidence interval [95% CI] 0.53–1.22), but had a positive association with progression (HRadj 1.67, 95% CI 1.05–2.67). For radiographic hip OA, African Americans had a significantly lower incidence (HRadj 0.44, 95% CI 0.27–0.71), whereas the association with progression was positive but nonsignificant (HRadj 1.46, 95% CI 0.53–4.01). In sensitivity analyses, the association with hip OA incidence was robust to a wide range of assumptions.
African Americans are protected against incident hip OA, but may be more susceptible to progressive knee OA.