• 1
    Wolfe F, Hawley DJ, Wilson K.The prevalence and meaning of fatigue in rheumatic disease.J Rheumatol1996;23:140717.
  • 2
    Hewlett S, Carr M, Ryan S, Kirwan J, Richards P, Carr A, et al.Outcomes generated by patients with rheumatoid arthritis: how important are they?Musculoskeletal Care2005;3:13142.
  • 3
    Belza Tack B.Fatigue in rheumatoid arthritis: conditions, strategies, and consequences.Arthritis Care Res1990;3:6570.
  • 4
    Hewlett S, Cockshott Z, Byron M, Kitchen K, Tipler S, Pope D, et al.Patients' perceptions of fatigue in rheumatoid arthritis: overwhelming, uncontrollable, ignored.Arthritis Rheum2005;53:697702.
  • 5
    Repping-Wuts H, Uitterhoeve R, van Riel P, van Achterberg T.Fatigue as experienced by patients with rheumatoid arthritis (RA): a qualitative study.Int J Nurs Stud2008;45:9951002.
  • 6
    Nikolaus S, Bode C, Taal E, van de Laar MA.New insights into the experience of fatigue among patients with rheumatoid arthritis: a qualitative study.Ann Rheum Dis2010;69:8957.
  • 7
    Hewlett S, Hehir M, Kirwan JR.Measuring fatigue in rheumatoid arthritis: a systematic review of scales in use.Arthritis Rheum2007;57:42939.
  • 8
    Repping-Wuts H, van Riel P, van Achterberg T.Fatigue in patients with rheumatoid arthritis: what is known and what is needed.Rheumatology (Oxford)2009;48:2079.
  • 9
    Hewlett S, Nicklin J, Treharne GJ. Fatigue in musculoskeletal conditions.2008. URL:
  • 10
    Hewlett S, Chalder T, Choy E, Cramp F, Davis B, Dures E, et al.Fatigue in rheumatoid arthritis: time for a conceptual model [editorial].Rheumatology (Oxford)2011;50:10046.
  • 11
    Stebbings S, Treharne GJ.Fatigue in rheumatic disease: an overview.Int J Clin Rheumatol2010;5:487502.
  • 12
    Rothman KJ, Greenland S, Lash TL.Modern epidemiology.Philadelphia:Wolters Kluwer, Lippincott Williams & Wilkins;2008.
  • 13
    Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions: version URL:
  • 14
    Belza BL, Henke CJ, Yelin EH, Epstein WV, Gilliss CL.Correlates of fatigue in older adults with rheumatoid arthritis.Nurs Res1993;42:939.
  • 15
    Davis MC, Zautra AJ, Younger J, Motivala SJ, Attrep J, Irwin MR.Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue.Brain Behav Immun2008;22:2432.
  • 16
    Van Hoogmoed D, Fransen J, Bleijenberg G, van Riel P.Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.Rheumatology (Oxford)2010;49:1294302.
  • 17
    Huyser BA, Parker JC, Thoreson R, Smarr KL, Johnson JC, Hoffman R.Predictors of subjective fatigue among individuals with rheumatoid arthritis.Arthritis Rheum1998;41:22307.
  • 18
    Pollard LC, Choy EH, Gonzalez J, Khoshaba B, Scott DL.Fatigue in rheumatoid arthritis reflects pain, not disease activity.Rheumatology (Oxford)2006;45:8859.
  • 19
    Riemsma RP, Rasker JJ, Taal E, Griep EN, Wouters JM, Wiegman O.Fatigue in rheumatoid arthritis: the role of self-efficacy and problematic social support.Br J Rheumatol1998;37:10426.
  • 20
    Thyberg I, Dahlstrom O, Thyberg M.Factors related to fatigue in women and men with early rheumatoid arthritis: the Swedish TIRA study.J Rehabil Med2009;41:90412.
  • 21
    Davis MC, Okun MA, Kruszewski D, Zautra AJ, Tennen H.Sex differences in the relations of positive and negative daily events and fatigue in adults with rheumatoid arthritis.J Pain2010;11:133847.
  • 22
    Stone AA, Broderick JE, Porter LS, Kaell AT.The experience of rheumatoid arthritis pain and fatigue: examining momentary reports and correlates over one week.Arthritis Care Res1997;10:18593.
  • 23
    Contreras-Yanez I, Cabiedes J, Villa AR, Rull-Gabayet M, Pascual-Ramos V.Persistence on therapy is a major determinant of patient-, physician- and laboratory-reported outcomes in recent-onset rheumatoid arthritis patients.Clin Exp Rheumatol2010;28:74851.
  • 24
    Stebbings S, Herbison P, Doyle TC, Treharne GJ, Highton J.A comparison of fatigue correlates in rheumatoid arthritis and osteoarthritis: disparity in associations with disability, anxiety and sleep disturbance.Rheumatology (Oxford)2010;49:3617.
  • 25
    Treharne GJ, Lyons AC, Hale ED, Goodchild CE, Booth DA, Kitas GD.Predictors of fatigue over 1 year among people with rheumatoid arthritis.Psychol Health Med2008;13:494504.
  • 26
    Dhir V, Lawrence A, Aggarwal A, Misra R.Fibromyalgia is common and adversely affects pain and fatigue perception in North Indian patients with rheumatoid arthritis.J Rheumatol2009;36:24438.
  • 27
    Bergman MJ, Shahouri SS, Shaver TS, Anderson JD, Weidensaul DN, Busch RE, et alIs fatigue an inflammatory variable in rheumatoid arthritis (RA)? Analyses of fatigue in RA, osteoarthritis, and fibromyalgia.J Rheumatol2009;36:278894.
  • 28
    Repping-Wuts H, Fransen J, van Achterberg T, Bleijenberg G, van Riel P.Persistent severe fatigue in patients with rheumatoid arthritis.J Clin Nurs2007;16:37783.
  • 29
    Fifield J, McQuillan J, Tennen H, Sheehan J, Reisine S, Hesselbrock V, et al.History of affective disorder and the temporal trajectory of fatigue in rheumatoid arthritis.Ann Behav Med2001;23:3441.
  • 30
    Brekke M, Hjortdahl P, Kvien TK.Self-efficacy and health status in rheumatoid arthritis: a two-year longitudinal observational study.Rheumatology (Oxford)2001;40:38792.
  • 31
    Scharloo M, Kaptein AA, Weinman JA, Hazes JM, Breedveld FC, Rooijmans HG.Predicting functional status in patients with rheumatoid arthritis.J Rheumatol1999;26:168693.
  • 32
    Mancuso CA, Rincon M, Sayles W, Paget SA.Psychosocial variables and fatigue: a longitudinal study comparing individuals with rheumatoid arthritis and healthy controls.J Rheumatol2006;33:1496502.
  • 33
    Jump RL, Fifield J, Tennen H, Reisine S, Giuliano AJ.History of affective disorder and the experience of fatigue in rheumatoid arthritis.Arthritis Rheum2004;51:23945.
  • 34
    Finan PH, Okun MA, Kruszewski D, Davis MC, Zautra AJ, Tennen H.Interplay of concurrent positive and negative interpersonal events in the prediction of daily negative affect and fatigue for rheumatoid arthritis patients.Health Psychol2010;29:42937.
  • 35
    Parrish BP, Zautra AJ, Davis MC.The role of positive and negative interpersonal events on daily fatigue in women with fibromyalgia, rheumatoid arthritis, and osteoarthritis.Health Psychol2008;27:694702.
  • 36
    Odegard S, Kvien TK, Uhlig T.Incidence of clinically important 10-year health status and disease activity levels in population-based cohorts with rheumatoid arthritis.J Rheumatol2008;35:5460.
  • 37
    Sokka T, Toloza S, Cutolo M, Kautiainen H, Makinen H, Gogus F, et al.Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study.Arthritis Res Ther2009;11:R7.
  • 38
    Chorus AM, Miedema HS, Boonen A, van der Linden SJ.Quality of life and work in patients with rheumatoid arthritis and ankylosing spondylitis of working age.Ann Rheum Dis2003;62:117884.
  • 39
    Wolfe F, Michaud K.Prevalence, risk, and risk factors for oral and ocular dryness with particular emphasis on rheumatoid arthritis.J Rheumatol2008;35:102330.
  • 40
    Yazici Y, Pincus T, Kautiainen H, Sokka T.Morning stiffness in patients with early rheumatoid arthritis is associated more strongly with functional disability than with joint swelling and erythrocyte sedimentation rate.J Rheumatol2004;31:17236.
  • 41
    Breedveld FC, Han C, Bala M, van der Heijde D, Baker D, Kavanaugh AF, et al.Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis.Ann Rheum Dis2005;64:525.
  • 42
    Gronning K, Rodevand E, Steinsbekk A.Paid work is associated with improved health-related quality of life in patients with rheumatoid arthritis.Clin Rheumatol2010;29:131722.
  • 43
    Rupp I, Boshuizen HC, Jacobi CE, Dinant HJ, van den Bos GA.Impact of fatigue on health-related quality of life in rheumatoid arthritis.Arthritis Rheum2004;51:57885.
  • 44
    Wolfe F, Michaud K.Proposed metrics for the determination of rheumatoid arthritis outcome and treatment success and failure.J Rheumatol2009;36:2733.
  • 45
    Katz PP.The stresses of rheumatoid arthritis: appraisals of perceived impact and coping efficacy.Arthritis Care Res1998;11:922.
  • 46
    Wolfe F, Michaud K, Pincus T.Fatigue, rheumatoid arthritis, and anti-tumor necrosis factor therapy: an investigation in 24,831 patients.J Rheumatol2004;31:211520.
  • 47
    Covic T, Tyson G, Spencer D, Howe G.Depression in rheumatoid arthritis patients: demographic, clinical, and psychological predictors.J Psychosom Res2006;60:46976.
  • 48
    Wolfe F, Michaud K.Predicting depression in rheumatoid arthritis: the signal importance of pain extent and fatigue, and comorbidity.Arthritis Rheum2009;61:66773.
  • 49
    Smedstad LM, Moum T, Vaglum P, Kvien TK.The impact of early rheumatoid arthritis on psychological distress: a comparison between 238 patients with RA and 116 matched controls.Scand J Rheumatol1996;25:37782.
  • 50
    De Croon EM, Sluiter JK, Nijssen TF, Kammeijer M, Dijkmans BA, Lankhorst GJ, et al.Work ability of Dutch employees with rheumatoid arthritis.Scand J Rheumatol2005;34:27783.
  • 51
    Mancuso CA, Rincon M, Sayles W, Paget SA.Longitudinal study of negative workplace events among employed rheumatoid arthritis patients and healthy controls.Arthritis Rheum2005;53:95864.
  • 52
    Davis MC, Affleck G, Zautra AJ, Tennen H.Daily interpersonal events in pain patients: applying action theory to chronic illness.J Clin Psychol2006;62:1097113.
  • 53
    Parker White C, White MB, Fox MA.Maternal fatigue and its relationship to the caregiving environment.Fam Syst Health2009;27:32545.
  • 54
    Waltz M.The disease process and utilization of health services in rheumatoid arthritis: the relative contributions of various markers of disease severity in explaining consumption patterns.Arthritis Care Res2000;13:7488.
  • 55
    Hewlett S, Dures E, Almeida C.Measures of fatigue: Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire (BRAF MDQ), Bristol Rheumatoid Arthritis Fatigue Numerical Rating Scales (BRAF NRS) for Severity, Effect, and Coping, Chalder Fatigue Questionnaire (CFQ), Checklist Individual Strength (CIS20R and CIS8R), Fatigue Severity Scale (FSS), Functional Assessment Chronic Illness Therapy (Fatigue) (FACIT-F), Multi-Dimensional Assessment of Fatigue (MAF), Multi-Dimensional Fatigue Inventory (MFI), Pediatric Quality of Life (PedsQL) Multi-Dimensional Fatigue Scale, Profile of Fatigue (ProF), Short Form 36 vitality subscale (SF-36 VT), and visual analog scales (VAS).Arthritis Care Res (Hoboken)2011;63 Suppl:S26386.
  • 56
    Nikolaus S, Bode C, Taal E, van de Laar MA.Which dimensions of fatigue should be measured in patients with rheumatoid arthritis? A Delphi study.Musculoskeletal Care2012;10:137.
  • 57
    Petticrew M, Roberts H. Exploring heterogeneity and publication bias. In: Petticrew M, Roberts H, editors.Systematic reviews in the social sciences: a practical guide.Malden (MA):Blackwell Publishing;2006. p.21546.