Dr. Maciewicz owns stock and/or stock options in AstraZeneca and has a patent pending for the osteoarthritis susceptibility gene.
Evidence of a Systemic Predisposition to Chondrocalcinosis and Association Between Chondrocalcinosis and Osteoarthritis at Distant Joints: A Cross-Sectional Study
Version of Record online: 1 JUL 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 7, pages 1052–1058, July 2013
How to Cite
Abhishek, A., Doherty, S., Maciewicz, R., Muir, K., Zhang, W. and Doherty, M. (2013), Evidence of a Systemic Predisposition to Chondrocalcinosis and Association Between Chondrocalcinosis and Osteoarthritis at Distant Joints: A Cross-Sectional Study. Arthritis Care Res, 65: 1052–1058. doi: 10.1002/acr.21952
- Issue online: 1 JUL 2013
- Version of Record online: 1 JUL 2013
- Accepted manuscript online: 17 JAN 2013 10:54AM EST
- Manuscript Accepted: 21 DEC 2012
- Manuscript Received: 16 JUN 2012
- AstraZeneca UK
- ICAC grant from Arthritis Research UK
To determine whether there is a systemic predisposition to chondrocalcinosis (CC) and to examine the association between CC and osteoarthritis (OA) at distant joints.
We performed a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle (GOAL) database (n = 3,170). All GOAL participants have had radiographs of the knees, hands, and pelvis performed. These were scored for OA at the knee, hip, wrist, and metacarpophalangeal (MCP) joints and for CC at the knee, hip, wrist, and symphysis pubis joints and for MCP joint calcification. Systemic predisposition to CC was established using cluster analysis. Odds ratios (95% confidence intervals) were used to examine the association between CC at the index and distant joints, CC and OA at the same joint, and index joint OA and distant joint CC. We adjusted for age, sex, and body mass index, and for distant joint OA, if required.
Joints with CC clustered together. This was also observed when participants with OA were excluded from the analysis. CC at each joint was associated with CC at distant joints. Knee and wrist OA but not hip OA was associated with CC at the same joint. MCP joint OA was associated with MCP joint calcification. Knee OA was associated with CC at other joints, and this was independent of OA at the distant joint. There was no association between hip OA and distant joint CC.
There is a systemic predisposition to the apparently sporadic CC. OA is associated with CC at the same joint and at distant joints, except hip OA, which is not associated with hip CC or with CC at distant joints.