Does Smoking Reduce the Progression of Osteoarthritis? Meta-Analysis of Observational Studies
Version of Record online: 1 JUL 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 7, pages 1026–1033, July 2013
How to Cite
Pearce, F., Hui, M., Ding, C., Doherty, M. and Zhang, W. (2013), Does Smoking Reduce the Progression of Osteoarthritis? Meta-Analysis of Observational Studies. Arthritis Care Res, 65: 1026–1033. doi: 10.1002/acr.21954
- Issue online: 1 JUL 2013
- Version of Record online: 1 JUL 2013
- Accepted manuscript online: 17 JAN 2013 10:54AM EST
- Manuscript Accepted: 21 DEC 2012
- Manuscript Received: 21 AUG 2012
To determine whether smoking reduces the progression of osteoarthritis (OA).
Observational studies examining smoking and progression of OA were systematically searched through Medline (1948–), EMBase (1980–), Web of Science, PubMed, and Google and relevant references. The search was last updated in May 2012. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were directly retrieved or calculated. Current standards for reporting meta-analyses of observational studies (Meta-Analysis of Observational Studies in Epidemiology) were followed. Quality-related aspects such as study design, setting, sample selection, definition of progression, and confounding bias were recorded. Stratified and meta-regression analyses were undertaken to examine the covariates.
Sixteen studies (976,564 participants) were identified from the literature. Overall, there was no significant association between smoking and progression of OA (OR 0.92; 95% CI 0.83, 1.02). There was moderate heterogeneity of results (I2 = 57.3%, P = 0.0024). Subgroup analyses showed some associations of marginal significance; however, meta-regression did not confirm any significant results.
There is no compelling evidence that smoking has a protective effect on the progression of OA. The results concur with a previous meta-analysis published by this group that showed no association between smoking and incidence of OA. Taken together, smoking does not appear to reduce either the incidence or progression of OA.