Drs. Virayavanich and Alizai contributed equally to this work.
Association of Frequent Knee Bending Activity With Focal Knee Lesions Detected With 3T Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative
Article first published online: 26 AUG 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 9, pages 1441–1448, September 2013
How to Cite
Virayavanich, W., Alizai, H., Baum, T., Nardo, L., Nevitt, M. C., Lynch, J. A., McCulloch, C. E. and Link, T. M. (2013), Association of Frequent Knee Bending Activity With Focal Knee Lesions Detected With 3T Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative. Arthritis Care Res, 65: 1441–1448. doi: 10.1002/acr.22017
- Issue published online: 26 AUG 2013
- Article first published online: 26 AUG 2013
- Accepted manuscript online: 1 APR 2013 12:31PM EST
- Manuscript Accepted: 20 MAR 2013
- Manuscript Received: 5 OCT 2012
- NIH. Grant Numbers: U01-AR059507, P50-AR060752
- Osteoarthritis Initiative (OAI). Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- NIH, a branch of the Department of Health and Human Services
- OAI Study Investigators
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- Pfizer, Inc.
- Foundation for the NIH
To evaluate the association of baseline frequent knee bending activities with the prevalence and progression of cartilage and meniscal abnormalities over 3 years and to assess the effect of frequent knee bending on the different knee compartments with 3T magnetic resonance imaging (MRI).
We studied 115 subjects without radiographic knee osteoarthritis (OA) but with risk factors for OA from the Osteoarthritis Initiative database. The inclusion criteria at baseline were age 45–55 years, body mass index of 19–27 kg/m2, Western Ontario and McMaster Universities Osteoarthritis Index pain score of 0, and Kellgren/Lawrence grade <2. Knee bending activities (kneeling, squatting, stair climbing, and weight lifting) were assessed by questionnaire at the baseline clinic visit. Cartilage and meniscal abnormalities were graded using the Whole-Organ MRI Score. Logistic regression was used to determine the association of frequent knee bending with cartilage and meniscal abnormalities.
Frequent knee bending activities were associated with an increased risk of prevalent cartilage lesions (odds ratio [OR] 3.63, 95% confidence interval [95% CI] 1.39–9.52), in particular in the patellofemoral compartment (OR 3.09, 95% CI 1.22–7.79). The increase in risk was higher in subjects involved in ≥2 knee bending activities. At 3-year followup, individuals reporting frequent knee bending were more likely to show progression of cartilage damage (OR 4.12, 95% CI 1.27–13.36) and meniscal abnormalities (OR 4.34, 95% CI 1.16–16.32).
Frequent knee bending activities were associated with a higher prevalence of knee cartilage lesions (particularly in the patellofemoral compartment) and with an increased risk of progression of cartilage and meniscal lesions in asymptomatic middle-aged subjects.