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ACR_22018_sm_SupplFig1.doc27KSupplementary Figure 1. Funnel plots of comparisons: A) bosentan versus placebo in reduction in mean number of new digital ulcer (DU) per patient; B) phosphodiesterase type 5 (PDE5) inhibitor versus placebo in complete DU healing; C) prostacyclin versus placebo in number of patients with new DU; D) prostacyclin versus placebo in number of patients with new DU. SMD Standard Mean Difference, RR is Relative Risk, SE is Standard Mean Difference or log of Relative Risk No publication bias was found when examining the Funnel plots.

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